| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Neural retina-specific leucine zipper protein; NRL; D14S46E; |
| Entrez GeneID | 4901; |
| WB Predicted band size | 26kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from N-terminal of human NRL. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及NRL(Neural Retina Leucine zipper)抗体的相关文献摘要(注：文献标题与作者为模拟示例，建议通过PubMed/Google Scholar验证具体信息)：
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1. **标题**: *NRL phosphorylation regulates rod photoreceptor differentiation in retinal development*
**作者**: Mears AJ, et al.
**摘要**: 研究揭示了NRL蛋白在视网膜感光细胞命运决定中的关键作用，通过特异性抗体检测发现磷酸化修饰的NRL可调控下游基因表达，促进视杆细胞而非视锥细胞的分化。
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2. **标题**: *Antibody-based profiling of NRL isoforms in mammalian retinas*
**作者**: Chen S, Swaroop A.
**摘要**: 开发了针对NRL不同异构体的单克隆抗体，利用免疫组化技术在小鼠和人类视网膜中定位NRL蛋白表达模式，证实其在光感受器前体细胞中的特异性分布。
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3. **标题**: *NRL mutations and antibody validation in inherited retinal diseases*
**作者**: Nishiguchi KM, et al.
**摘要**: 通过患者基因测序发现NRL基因突变与视网膜色素变性相关，并利用Western blot和免疫荧光抗体验证突变导致NRL蛋白稳定性下降，影响光感受器发育。
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**提示**：实际文献需通过关键词"NRL antibody"或"NRL protein retina"在学术数据库检索，重点关注抗体应用场景(如染色、Western blot)或疾病机制研究。推荐查阅《Investigative Ophthalmology & Visual Science》或《Development》等期刊相关论文。
NRL (Neural Retina Leucine zipper) antibodies are primarily used in research to study the NRL protein, a critical transcription factor in retinal development and function. NRL, a member of the basic motif-leucine zipper (bZIP) family, is essential for specifying rod photoreceptor cells in the mammalian retina. It regulates the expression of rod-specific genes, including rhodopsin, by interacting with other transcriptional regulators like CRX. Mutations in the NRL gene are linked to retinal degenerative diseases, such as retinitis pigmentosa, highlighting its role in maintaining photoreceptor health.
NRL antibodies are vital tools in immunohistochemistry, Western blotting, and immunofluorescence to detect NRL expression patterns in retinal tissues. Studies using these antibodies have revealed NRL's dynamic expression during retinal differentiation, its role in cell fate determination, and its interplay with signaling pathways like Notch and Wnt. Additionally, NRL antibodies aid in exploring disease mechanisms, drug screening, and gene therapy approaches for inherited retinal disorders. Their specificity enables researchers to dissect the molecular cascades governing photoreceptor development and degeneration, offering insights into potential therapeutic targets for vision-related diseases.
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