Rabbit Polyclonal NRSN1 Antibody

The Neurensin-1 (NRSN1) gene encodes a small transmembrane protein predominantly expressed in neuronal tissues and some cancer cells. It plays roles in vesicle trafficking, synaptic membrane formation, and neuronal differentiation. NRSN1 is also implicated in non-neuronal contexts, particularly in cancer progression, where its overexpression correlates with poor prognosis in breast, ovarian, and lung cancers. Antibodies targeting NRSN1 are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to explore NRSN1's role in neurological disorders (e.g., schizophrenia, Alzheimer's disease) and oncogenic mechanisms. Some studies suggest NRSN1 interacts with growth factor signaling pathways, making it a potential therapeutic target or diagnostic biomarker. Commercial NRSN1 antibodies are typically raised against specific epitopes, such as the C-terminal region, and validated for specificity across human and model organism samples. Researchers prioritize antibodies with high affinity and minimal cross-reactivity to ensure accuracy in detecting endogenous NRSN1. which has low baseline expression in normal tissues. Ongoing research aims to clarify its dual roles in neuroprotection and tumorigenesis, highlighting the antibody's value in both basic and translational studies.