| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Neuroblastoma breakpoint family member 7; NBPF7; |
| Entrez GeneID | 343505; |
| WB Predicted band size | 48kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human NBPF7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NBPF7抗体的3-4条虚构参考文献示例(注意：以下内容为模拟生成，实际文献需通过学术数据库验证)：
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1. **文献名称**: "NBPF7 Antibody as a Novel Biomarker in Neuroblastoma Progression"
**作者**: Smith J, et al.
**摘要**: 本研究通过免疫组化和Western blot分析，发现NBPF7在神经母细胞瘤中高表达，并与患者不良预后相关。NBPF7抗体特异性检测到其在肿瘤组织中的定位，提示其可能作为潜在治疗靶点或诊断标志物。
2. **文献名称**: "Epitope Mapping of NBPF7 Antibodies in Neurodegenerative Disorders"
**作者**: Chen L, et al.
**摘要**: 作者利用噬菌体展示技术解析了NBPF7抗体的抗原表位，发现其与阿尔茨海默病患者脑组织中异常蛋白聚集存在交叉反应，为研究NBPF7在神经退行性疾病中的作用提供了新工具。
3. **文献名称**: "NBPF7 Expression and Antibody Development in Glioblastoma"
**作者**: Müller R, et al.
**摘要**: 研究开发了一种高灵敏度的兔源多克隆NBPF7抗体，通过流式细胞术和免疫荧光验证其在胶质母细胞瘤细胞系中的表达差异，提示NBPF7可能参与肿瘤侵袭性调控。
4. **文献名称**: "Structural Insights into NBPF7 Antibody Binding via Cryo-EM"
**作者**: Wang Y, et al.
**摘要**: 通过冷冻电镜技术解析了NBPF7蛋白与其单克隆抗体的复合物结构，揭示了抗体结合界面与NBPF7功能域的关联，为基于结构的药物设计奠定基础。
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**注意**：以上文献为示例性质，实际研究中请通过PubMed、Google Scholar等平台检索真实发表的文献(关键词：NBPF7 antibody, neuroblastoma, biomarker)。
The NBPF7 (Neuroblastoma Breakpoint Family Member 7) gene belongs to the NBPF family, a group of primate-specific genes characterized by repetitive Olduvai (DUF1220) protein domains. These genes are implicated in brain development and neurodevelopmental disorders. NBPF7. located on human chromosome 1q21.1. has garnered attention due to its association with genomic instability regions linked to neurodevelopmental conditions like autism and schizophrenia. The NBPF7 protein is hypothesized to play roles in neuronal differentiation, synaptic plasticity, or cell cycle regulation, though its precise molecular functions remain under investigation.
Antibodies targeting NBPF7 are primarily used in research to study its expression patterns, subcellular localization, and interactions. Commercial NBPF7 antibodies are typically raised in rabbits or mice against synthetic peptides corresponding to specific regions of the human protein. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Validation data often include reactivity in brain tissue or cell lines expressing endogenous NBPF7. Challenges exist in ensuring specificity due to potential cross-reactivity with other NBPF family members sharing homologous DUF1220 domains. Recent studies using these antibodies have explored NBPF7's dysregulation in cancers (e.g., neuroblastoma) and neurological disorders, contributing to emerging evidence of its role in disease pathogenesis. Continued antibody development aims to improve isoform discrimination and support functional studies of this evolutionarily recent gene family.
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