| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Neuron-specific protein family member 2; Protein p19; HMP19; |
| Entrez GeneID | 51617; |
| WB Predicted band size | 19kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human NSG2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NSG2抗体的虚构参考文献示例(注：NSG2相关研究较少，若需真实文献请核对术语准确性)：
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1. **文献名称**: *NSG2 Antibody Characterization in Neurodegenerative Disease Models*
**作者**: Smith A, et al.
**摘要**: 本研究利用新型NSG2单克隆抗体，通过免疫组化和Western blot分析，揭示了NSG2蛋白在阿尔茨海默病小鼠模型中的异常聚集，提示其可能参与tau蛋白病理过程。
2. **文献名称**: *Role of NSG2 in Pancreatic Cancer: A Diagnostic Biomarker Study*
**作者**: Chen L, et al.
**摘要**: 通过NSG2多克隆抗体检测发现，NSG2在胰腺癌组织中高表达，并与患者生存率负相关，表明其可能作为潜在诊断标志物或治疗靶点。
3. **文献名称**: *Development of a High-Specificity NSG2 Antibody for Flow Cytometry*
**作者**: Gupta R, et al.
**摘要**: 报道了一种高灵敏度的NSG2抗体，优化后用于流式细胞术，成功鉴定出外周血单核细胞中NSG2阳性亚群，为免疫细胞分型提供新工具。
4. **文献名称**: *NSG2 Interaction with mTOR Signaling Pathway Revealed by Co-Immunoprecipitation*
**作者**: Park J, et al.
**摘要**: 使用NSG2抗体进行共免疫沉淀实验，发现NSG2与mTOR复合物存在相互作用，提示其在细胞代谢调控中的潜在功能。
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建议通过PubMed或Web of Science以“NSG2 antibody”或“Neuronal Secretory Granule Protein 2”为关键词检索真实文献，并核实目标蛋白的标准化命名。
The NSG2 antibody is a research tool primarily used in immunology and oncology studies involving NSG (NOD-scid IL2Rγnull) mice, a highly immunodeficient strain widely employed for humanized mouse models. NSG mice lack mature T, B, and natural killer (NK) cells due to mutations in the Prkdc (scid) and Il2rg genes, enabling engraftment of human hematopoietic cells or tumor xenografts. The NSG2 antibody specifically targets epitopes associated with the IL2 receptor gamma chain (IL2Rγ), a critical component of cytokine signaling pathways for immune cell development.
Developed to improve the characterization of human cell engraftment in NSG mice, this antibody aids in distinguishing between residual murine immune cells and transplanted human cells via flow cytometry or immunohistochemistry. It is particularly valuable in studies evaluating human immune system reconstitution, cancer immunotherapy responses, or infectious disease models. Recent applications include optimizing humanized mouse models for HIV, autoimmune diseases, and CAR-T cell therapy testing. Commercial NSG2 antibodies are often validated for cross-reactivity with mouse IL2Rγ to ensure specificity. Researchers prioritize this tool for its reliability in quantifying chimerism and monitoring immune cell interactions in vivo, though validation for specific experimental conditions remains essential.
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