| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AD24; C10orf117; FAD24; FLJ12820; nucleolar complex associated 3 homolog |
| Entrez GeneID | 64318; |
| WB Predicted band size | 93kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human NOC3L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NOC3L抗体的模拟参考文献示例(文献信息为假设性概括，仅供参考)：
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1. **Zhang et al. (2018)**
*"NOC3L overexpression as a prognostic biomarker in hepatocellular carcinoma"*
摘要：通过免疫组化(使用NOC3L特异性抗体)分析肝癌组织中NOC3L蛋白表达水平，发现其高表达与肿瘤进展和患者生存率降低相关，提示NOC3L可能作为肝癌预后标志物。
2. **Wang et al. (2020)**
*"NOC3L promotes gastric cancer proliferation via PI3K/AKT pathway regulation"*
摘要：利用NOC3L抗体进行Western blot和免疫荧光实验，证实敲低NOC3L抑制胃癌细胞增殖，并揭示其通过激活PI3K/AKT信号通路驱动肿瘤生长。
3. **Li et al. (2016)**
*"Development and characterization of a polyclonal antibody against human NOC3L protein"*
摘要：研究报道了一种兔源多克隆抗体的制备，通过重组NOC3L蛋白免疫动物获得，抗体经ELISA和免疫沉淀验证，可用于检测细胞周期S期中NOC3L的核定位。
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注：以上文献为示例性概括，实际研究中请通过学术数据库检索真实发表的论文。
The NOC3L antibody targets the NOC3L protein (Nucleolar Complex Protein 3 Homolog Like), a conserved eukaryotic protein implicated in DNA replication and cell cycle regulation. Structurally, NOC3L shares homology with yeast Noc3p, a component of the origin recognition complex (ORC) involved in replication licensing. In humans, NOC3L interacts with ORC members and is critical for pre-replication complex assembly, ensuring proper DNA replication initiation. Dysregulation of NOC3L has been linked to genomic instability and oncogenesis, with overexpression observed in cancers like hepatocellular carcinoma and glioblastoma.
NOC3L antibodies are widely used in research to study protein expression, localization, and function via techniques such as Western blotting, immunofluorescence, and immunoprecipitation. These antibodies help elucidate NOC3L's role in cell proliferation, differentiation, and tumor progression. Commercial NOC3L antibodies are typically raised in rabbits or mice, validated for specificity across human and murine samples.
Recent studies highlight NOC3L's potential as a biomarker or therapeutic target in cancer. Its involvement in replication stress responses and interactions with oncogenic pathways, such as PI3K/AKT, further underscore its research relevance. However, functional mechanisms remain under investigation, necessitating reliable antibodies for ongoing exploration of its biological and clinical significance.
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