| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Oxidation resistance protein 1; |
| Entrez GeneID | 55074; |
| WB Predicted band size | 85kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human OXR1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于OXR1抗体的示例参考文献(注：文献为示例性内容，非真实存在)：
1. **文献名称**: "OXR1 modulates oxidative stress resistance in neurodegenerative disease models"
**作者**: Smith A, et al.
**摘要**: 研究利用OXR1特异性抗体，通过Western blot和免疫荧光技术，发现OXR1蛋白在小鼠脑组织中的表达水平与帕金森病模型中神经元存活率呈正相关，提示其抗氧化应激的保护作用。
2. **文献名称**: "Antibody-based detection of OXR1 in age-related macular degeneration"
**作者**: Chen L, et al.
**摘要**: 通过开发高特异性OXR1单克隆抗体，研究者证实视网膜色素上皮细胞中OXR1蛋白的异常表达与氧化损伤导致的年龄相关性黄斑变性(AMD)病理进程相关。
3. **文献名称**: "OXR1 antibody reveals tissue-specific expression patterns in mammalian development"
**作者**: Johnson R, et al.
**摘要**: 使用OXR1多克隆抗体进行免疫组化分析，揭示了OXR1在小鼠胚胎发育过程中于神经系统和心脏组织中的动态表达，提示其在器官形成中的潜在调控功能。
4. **文献名称**: "The role of OXR1 in glioblastoma: Insights from antibody-mediated knockdown"
**作者**: Kim H, et al.
**摘要**: 结合OXR1抗体和RNA干扰技术，研究发现抑制OXR1表达可增强胶质母细胞瘤细胞对放疗的敏感性，表明OXR1可能作为癌症治疗的新靶点。
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**说明**：以上文献为基于领域知识的模拟内容，实际文献需通过PubMed/Google Scholar等平台检索关键词“OXR1 antibody”或“OXR1 protein function”获取。
The OXR1 (Oxidation Resistance 1) antibody is a tool used to study the OXR1 protein, which plays a critical role in cellular defense mechanisms against oxidative stress. Initially identified in yeast, the OXR1 gene is evolutionarily conserved and implicated in DNA repair, mitochondrial function, and neuroprotection. The protein contains conserved domains, including the TBC/RabGAP domain and PRESTAT module, linked to its antioxidant and signaling functions. Research shows OXR1 is vital for neuronal survival, with deficiencies leading to neurodegeneration in animal models. It interacts with pathways involving Nrf2 and mTOR, modulating stress responses and autophagy.
OXR1 antibodies are widely used in Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression levels, localization, and dynamics in tissues or cultured cells. They help explore OXR1's role in diseases like Alzheimer's, Parkinson's, and cancer, where oxidative damage contributes to pathology. Commercial OXR1 antibodies are typically raised in rabbits or mice against specific epitopes, with validation in knockout models to ensure specificity. Recent studies also highlight its potential as a therapeutic target, driving interest in reliable detection tools. Understanding OXR1's mechanisms through antibody-based assays remains key to unraveling its protective functions in redox homeostasis and disease.
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