| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EC 2.3.1.-; ZDH7; ZDHC7; zinc finger 370; ZNF370 |
| Entrez GeneID | 55625; |
| WB Predicted band size | 35kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from C-terminal of human ZDHHC7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZDHHC7抗体的3篇参考文献示例(注：以下内容为模拟文献，实际文献需通过学术数据库查询)：
1. **文献名称**：*"ZDHHC7-mediated palmitoylation regulates EGFR signaling and cancer cell proliferation"*
**作者**：Smith A, et al.
**摘要**：该研究利用特异性ZDHHC7抗体，通过免疫沉淀和Western blot技术，揭示了ZDHHC7在表皮生长因子受体(EGFR)棕榈酰化修饰中的作用，证明其通过调控EGFR膜定位影响肿瘤细胞增殖。
2. **文献名称**：*"Role of ZDHHC7 in neuronal protein trafficking: Insights from antibody-based knockout validation"*
**作者**：Chen L, et al.
**摘要**：作者开发了一种高特异性ZDHHC7抗体，结合CRISPR敲除模型，证实ZDHHC7通过棕榈酰化突触相关蛋白(如PSD-95)参与神经元突触可塑性，抗体在免疫荧光和脑组织切片染色中表现出高灵敏度。
3. **文献名称**：*"Antibody profiling of DHHC family members identifies ZDHHC7 as a potential biomarker in colorectal cancer"*
**作者**：Wang Y, et al.
**摘要**：研究通过高通量抗体筛选平台分析DHHC家族表达，发现ZDHHC7在结直肠癌组织中显著高表达。使用商业化ZDHHC7抗体验证其与患者预后的相关性，提示其作为治疗靶点的潜力。
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**提示**：实际文献建议通过PubMed、Google Scholar检索关键词“ZDHHC7 antibody”或结合研究场景(如“ZDHHC7 cancer”)，筛选应用该抗体的功能研究论文。部分抗体公司(如Abcam、CST)的产品说明书也会引用相关文献。
ZDHHC7 antibody is a research tool designed to detect ZDHHC7. a member of the DHHC (Asp-His-His-Cys) protein family. These enzymes catalyze protein palmitoylation, a post-translational modification critical for membrane anchoring, protein trafficking, and signaling. ZDHHC7. encoded by the *ZDHHC7* gene, localizes to the Golgi apparatus and endoplasmic reticulum, where it mediates palmitate transfer to substrate proteins. It has been implicated in neurological processes, cancer progression, and immune regulation, though its full functional spectrum remains under investigation.
The antibody is typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments specific to ZDHHC7. It enables techniques such as Western blotting, immunofluorescence, and immunohistochemistry to study ZDHHC7 expression, localization, and interactions. Validated antibodies show specificity for ZDHHC7 over other DHHC family members, often confirmed by knockout controls or siRNA knockdown experiments.
Research applications include exploring ZDHHC7's role in diseases. For example, aberrant ZDHHC7 expression correlates with tumor metastasis and neurotransmitter receptor dysfunction. Commercial antibodies often provide data on reactivity across species (human, mouse, rat) and tissues. However, users must optimize conditions (e.g., dilution, fixation) due to variability in sample preparation and epitope accessibility. As palmitoylation gains attention in drug discovery, ZDHHC7 antibodies remain vital for dissecting its pathophysiological contributions.
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