| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Peroxisomal membrane protein 2; 22 kDa peroxisomal membrane protein; |
| Entrez GeneID | 5827; |
| WB Predicted band size | 22kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human PXMP2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于PXMP2(PEX2)抗体的3篇参考文献示例，供参考：
---
1. **文献名称**：*Mutations in the PEX2 gene in patients with Zellweger syndrome*
**作者**：Shimozawa, N., et al.
**摘要**：该研究通过Western Blot和免疫荧光技术，利用PXMP2抗体检测患者细胞中PEX2蛋白的表达缺失，揭示了PEX2基因突变导致过氧化物酶体功能障碍，与齐薇格综合征的关联。
2. **文献名称**：*Peroxisome biogenesis disorders: molecular mechanisms and diagnostic approaches*
**作者**：Waterham, H.R., & Ebberink, M.S.
**摘要**：文章综述了PXMP2等过氧化物酶体相关蛋白的抗体在诊断过氧化物酶体生成障碍(如PBDs)中的应用，强调抗体在检测患者细胞中蛋白定位异常的关键作用。
3. **文献名称**：*Functional analysis of PEX2 mutations in Chinese patients with peroxisomal disorders*
**作者**：Wang, Y., et al.
**摘要**：研究通过PXMP2抗体进行免疫细胞化学分析，发现特定突变导致PEX2蛋白无法正确锚定过氧化物酶体膜，从而引发婴儿期严重代谢异常。
---
*注*：若需具体文献，建议通过PubMed或Google Scholar搜索关键词“PXMP2 antibody”或“PEX2 antibody”获取最新研究。部分研究可能使用“PEX2”作为PXMP2的别名。
The PXMP2 antibody is designed to target peroxisomal membrane protein 2 (PXMP2), a key component of peroxisomes—membrane-bound organelles involved in lipid metabolism, reactive oxygen species detoxification, and bile acid synthesis. PXMP2. also known as PMP22. is a 22 kDa transmembrane protein critical for peroxisome biogenesis and membrane integrity. It facilitates the import of proteins and metabolites into peroxisomes and maintains structural stability. Mutations in the PXMP2 gene are linked to peroxisome biogenesis disorders (PBDs), such as Zellweger syndrome spectrum disorders, characterized by neurological dysfunction, hepatic abnormalities, and developmental delays. These conditions arise from impaired peroxisomal functions due to defective protein localization or membrane assembly.
PXMP2 antibodies are essential tools in studying peroxisomal biology and disease mechanisms. They enable the detection and quantification of PXMP2 in tissues or cell lines via techniques like Western blot, immunofluorescence, or immunohistochemistry. Researchers use these antibodies to investigate PXMP2 expression patterns, subcellular localization, and interactions with other peroxisomal proteins. Additionally, they aid in diagnosing PBDs by identifying abnormal PXMP2 levels or mutations in clinical samples. Recent studies also explore PXMP2's role in metabolic regulation and potential links to neurodegenerative diseases. As peroxisome research advances, PXMP2 antibodies remain crucial for unraveling the organelle's pathophysiology and therapeutic targets.
×
