| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein; ATP-dependent helicase PRIC285; PPAR-alpha-interacting complex protein 285; PPAR-gamma DNA-binding domain-interacting protein 1; PPAR-gamma DBD-interacting protein 1 |
| Entrez GeneID | 85441; |
| WB Predicted band size | 295kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human PRIC285. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于PRIC285抗体的虚构参考文献示例(请注意，PRIC285抗体相关文献可能较少，实际引用需通过学术数据库核实)：
---
1. **文献名称**: *PRIC285 Antibody Characterization in Epigenetic Regulation*
**作者**: Li, X.; Chen, Y.; Wang, L.
**摘要**: 本研究验证了PRIC285抗体在染色质免疫沉淀(ChIP)中的特异性，证实其靶向组蛋白修饰酶复合物中的PRIC285蛋白，并揭示其在表观遗传调控中的功能。结果显示，PRIC285缺失导致细胞分化异常。
2. **文献名称**: *Role of PRIC285 in Mitochondrial Function: Insights from Knockout Models*
**作者**: Smith, J.; Brown, K.
**摘要**: 通过PRIC285抗体检测，发现该蛋白在线粒体代谢通路中关键作用。实验表明，PRIC285敲除小鼠出现能量代谢紊乱，提示其与代谢性疾病潜在关联。
3. **文献名称**: *Development of a High-Affinity PRIC285 Monoclonal Antibody for Diagnostic Applications*
**作者**: Gupta, R.; Tanaka, H.
**摘要**: 报道了一种新型PRIC285单克隆抗体的开发，验证其在ELISA和免疫组化中的高灵敏度和特异性，为癌症生物标志物检测提供新工具。
---
**备注**：以上为模拟文献，实际研究中请通过PubMed、Google Scholar等平台检索真实文献(如存在)。若需具体领域文献，建议补充PRIC285抗体的研究背景或靶点信息。
The PRIC285 antibody is a research tool designed to detect PRIC285 (Peroxisomal Proliferator-Activated Receptor A Interacting Complex 285), a protein also known as PBP (PPAR-binding protein) or TRAP220 (thyroid hormone receptor-associated protein 220). PRIC285 is a critical component of the multi-subunit MED1 complex (Mediator complex subunit 1), which facilitates transcriptional regulation by bridging DNA-bound transcription factors and the RNA polymerase II machinery. It plays a pivotal role in nuclear receptor signaling, particularly for peroxisome proliferator-activated receptors (PPARs), thyroid hormone receptors, and estrogen receptors, influencing metabolic processes, cell differentiation, and hormonal responses.
Developed primarily in rabbit or mouse hosts, the PRIC285 antibody is used in applications like Western blotting, immunoprecipitation, and immunofluorescence to study protein expression, localization, and interactions. Its specificity enables researchers to explore PRIC285’s role in transcriptional coactivation, lipid metabolism, and diseases such as obesity, diabetes, and cancer. Studies using this antibody have contributed to understanding how dysregulation of Mediator complex subunits impacts gene expression and cellular homeostasis. Validated for reactivity in human, mouse, and rat samples, it remains a key reagent in molecular biology and metabolic research.
×
