| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Phosphoinositide 3-kinase regulatory subunit 5; PI3-kinase regulatory subunit 5; PI3-kinase p101 subunit; PtdIns-3-kinase p101; p101-PI3K |
| Entrez GeneID | 23533; |
| WB Predicted band size | 100kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human PIK3R5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PIK3R5抗体的3篇示例参考文献(内容为示例性概括，非真实文献)：
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1. **文献名称**：*PIK3R5 regulates macrophage polarization through the PI3K/AKT pathway in inflammatory diseases*
**作者**：Smith A, et al.
**摘要**：研究通过PIK3R5特异性抗体揭示了其在巨噬细胞极化中的作用，发现PIK3R5通过调控PI3K/AKT信号通路影响炎症性疾病中促炎/抗炎表型平衡。
2. **文献名称**：*Development and validation of a monoclonal antibody targeting PIK3R5 for cancer immunotherapy*
**作者**：Chen L, et al.
**摘要**：报道了一种新型抗PIK3R5单克隆抗体的开发，验证其通过阻断PI3Kγ复合体抑制肿瘤微环境中免疫抑制性细胞的功能，增强抗肿瘤免疫应答。
3. **文献名称**：*PIK3R5 as a potential biomarker in chronic lymphocytic leukemia: insights from antibody-based proteomic analysis*
**作者**：Wang Y, et al.
**摘要**：利用抗PIK3R5抗体进行蛋白质组学分析，发现其在慢性淋巴细胞白血病(CLL)患者中高表达，提示其可能作为疾病进展和耐药性的潜在生物标志物。
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**注意**：以上内容为模拟生成，实际文献需通过PubMed、Web of Science等学术平台检索关键词“PIK3R5 antibody”或“PIK3R5 function”获取。
The PIK3R5 antibody targets the phosphoinositide-3-kinase regulatory subunit 5 (PIK3R5), a regulatory component of the class III phosphatidylinositol 3-kinase (PI3K) complex. PIK3R5. also known as VPS15. plays a critical role in intracellular vesicular trafficking, autophagy, and endosomal sorting by forming a heterodimer with the catalytic subunit VPS34 (PIK3C3). This complex regulates the production of phosphatidylinositol 3-phosphate (PI3P), a lipid signaling molecule essential for membrane dynamics and cellular homeostasis. Dysregulation of PIK3R5/VPS34 activity has been implicated in neurodegenerative diseases, cancer, and metabolic disorders, making it a focus of therapeutic research.
PIK3R5 antibodies are widely used in molecular and cellular studies to investigate the expression, localization, and function of the protein in various biological contexts. These antibodies enable detection via techniques such as Western blotting, immunofluorescence, and immunohistochemistry, aiding in the exploration of PIK3R5’s role in autophagy, lysosomal pathways, and disease mechanisms. Researchers also utilize PIK3R5-specific antibodies to assess protein-protein interactions and post-translational modifications, which are critical for understanding regulatory mechanisms. Available as monoclonal or polyclonal variants, these antibodies are typically validated in human, mouse, or rat samples. Their application extends to preclinical studies evaluating PI3K pathway inhibitors, highlighting their importance in both basic research and drug development.
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