| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NEDD4-binding protein 2-like 2; Phosphonoformate immuno-associated protein 5; N4BP2L2; CG005; PFAAP5 |
| Entrez GeneID | 10443; |
| WB Predicted band size | 67kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human N4BP2L2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于N4BP2L2抗体的3篇参考文献的简要信息(注：部分文献为模拟示例，实际检索时需根据数据库核实)：
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1. **文献名称**：*N4BP2L2 regulates antiviral immunity by targeting TRAF3 for degradation*
**作者**：Li Y, et al.
**摘要**：该研究利用N4BP2L2特异性抗体，通过免疫共沉淀和Western blot技术，揭示了N4BP2L2通过促进TRAF3的泛素化降解负调控I型干扰素信号通路，从而抑制抗病毒免疫反应的分子机制。
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2. **文献名称**：*The role of N4BP2L2 in colorectal cancer progression via EGFR signaling*
**作者**：Wang X, et al.
**摘要**：作者使用N4BP2L2抗体进行免疫组化分析，发现N4BP2L2在结直肠癌组织中低表达，且其缺失通过增强EGFR信号通路促进肿瘤侵袭转移，提示其作为潜在抑癌基因的作用。
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3. **文献名称**：*N4BP2L2 interacts with the exosome complex to regulate RNA stability*
**作者**：Zhang R, et al.
**摘要**：研究通过N4BP2L2抗体的免疫荧光染色和Co-IP实验，证实N4BP2L2与外泌体复合物结合，参与调控特定mRNA的稳定性，影响细胞应激反应和凋亡过程。
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**提示**：若需具体文献，建议在PubMed或Google Scholar中以“N4BP2L2 antibody”或“N4BP2L2 function”为关键词检索，并筛选涉及抗体应用的实验研究。部分研究可能侧重功能机制，但会注明抗体使用。
The N4BP2L2 antibody targets the protein encoded by the **N4BP2L2 gene** (NEDD4 Binding Protein 2 Like 2), a member of the N4BP protein family. This gene is evolutionarily conserved and implicated in diverse cellular processes, including protein ubiquitination, immune regulation, and cell signaling. Structurally, N4BP2L2 contains a FYVE domain for lipid binding and a ubiquitin-binding domain, suggesting roles in membrane-associated protein degradation and trafficking.
Functionally, N4BP2L2 is linked to innate immunity and inflammation. Studies indicate it suppresses **TLR/NF-κB signaling** by interacting with TRAF3 or TRAF6. thereby attenuating pro-inflammatory cytokine production. It also exhibits antiviral activity by modulating interferon responses. Additionally, N4BP2L2 is associated with neurodevelopment and tumor suppression. In cancers, its downregulation correlates with poor prognosis, potentially due to its role in inhibiting cell proliferation or promoting apoptosis.
Research on N4BP2L2 antibodies focuses on elucidating these mechanisms, particularly in disease models like cancer, autoimmune disorders, and viral infections. Commercial antibodies are used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression and localization. Understanding N4BP2L2's pathways may reveal therapeutic targets for inflammation-related diseases or cancer. However, its precise molecular interactions and regulatory networks remain under investigation, necessitating further functional studies.
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