| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | rab GTPase-binding effector protein 2; rabaptin-5beta; rabe2; rabpt5b; |
| Entrez GeneID | 79874; |
| WB Predicted band size | 64kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human RABEP2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于真实文献的示例格式(注：由于无法实时访问数据库，以下为假设性示例，建议通过学术引擎验证)：
1. **标题**: "RABEP2 modulates endosomal trafficking and EGFR signaling"
**作者**: Tanaka K, et al.
**摘要**: 研究利用RABEP2特异性抗体进行免疫印迹和免疫荧光，揭示其在调节EGFR内吞及信号传导中的作用，影响癌细胞增殖。
2. **标题**: "RABEP2 interaction with Rab5 in early endosome organization"
**作者**: Müller M, et al.
**摘要**: 通过抗体介导的免疫沉淀发现RABEP2与Rab5的相互作用，阐明其在早期内体膜形态维持中的功能。
3. **标题**: "RABEP2 expression profiling in neurodegenerative models"
**作者**: Chen L, et al.
**摘要**: 采用RABEP2抗体进行脑组织免疫组化，显示其在阿尔茨海默病模型中的表达下调，提示与神经元运输障碍相关。
**检索建议**：
- 使用PubMed或Google Scholar，关键词“RABEP2 antibody”、“RABEP2 function”。
- 筛选方法部分提及抗体应用的论文，重点关注细胞运输、疾病机制研究。
- 检查引用这些研究的后续论文，可能发现更多相关文献。
如需具体文献详情，建议通过机构图书馆数据库检索。
The RABEP2 antibody is designed to detect Rab GTPase-binding effector protein 2 (RABEP2), a member of the Rab effector family involved in intracellular membrane trafficking and vesicle transport. RABEP2 interacts with Rab proteins, particularly Rab4 and Rab5. which regulate endosomal sorting, receptor recycling, and receptor-mediated endocytosis. It plays a role in maintaining endosome morphology and trafficking efficiency, impacting cellular processes like signal transduction, nutrient uptake, and immune responses. Dysregulation of RABEP2 has been linked to pathologies, including cancers and neurodevelopmental disorders, though its exact mechanisms remain under investigation.
The RABEP2 antibody is widely used in research to study protein expression, localization, and function via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Its application aids in elucidating RABEP2's role in vesicular transport pathways and disease contexts. Commercial RABEP2 antibodies are typically validated for specificity using knockout controls or siRNA-mediated depletion. Recent studies highlight its potential as a biomarker in tumor progression, emphasizing its importance in both basic research and clinical diagnostics. Further exploration of RABEP2 interactions may uncover therapeutic targets for trafficking-related diseases.
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