Rabbit Polyclonal RIMS4 Antibody

The RIMS4 antibody targets the protein Rab3-interacting molecule 4 (RIMS4), a member of the RIMS family crucial for synaptic vesicle exocytosis and neurotransmitter release. RIMS proteins, encoded by the *RIMS1-4* genes, act as scaffolding molecules in the presynaptic active zone, interacting with Rab3 GTPases, Munc13. and voltage-gated calcium channels to regulate synaptic vesicle priming and calcium-triggered release. RIMS4. a shorter splice variant of *RIMS1*, lacks certain domains but retains key interaction sites, suggesting specialized roles in neuronal or endocrine signaling. It is prominently expressed in the brain and retina, particularly in retinal bipolar cells, where it modulates synaptic transmission. Dysregulation of RIMS proteins is linked to neuropsychiatric disorders (e.g., autism, schizophrenia) and retinal pathologies. RIMS4 antibodies are vital tools for studying synaptic architecture, protein localization, and molecular mechanisms underlying synaptic dysfunction. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore RIMS4's tissue distribution, expression changes in disease models, and interactions within synaptic complexes. Recent studies also investigate its potential involvement in neurodevelopmental disorders and retinal degenerative diseases, highlighting its functional diversity beyond canonical RIMS1 pathways.