| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Na(+)/PI cotransporter 3; NPT3; sodium phosphate transporter 3; sodium/phosphate cotransporter 3; solute carrier family 17 (sodium phosphate) |
| Entrez GeneID | 10246; |
| WB Predicted band size | 47kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human SLC17A2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SLC17A2抗体的3篇文献示例(注：文献为虚拟示例，实际引用需核实)：
1. **文献名称**：*"SLC17A2 as a vesicular glutamate transporter in pancreatic β-cells"*
**作者**：Tanaka K, et al.
**摘要**：本研究通过SLC17A2特异性抗体验证其在胰岛β细胞中的表达，发现其参与调控胰岛素分泌囊泡的谷氨酸转运，可能与糖尿病病理相关。
2. **文献名称**：*"Localization of SLC17A2 protein in human kidney using monoclonal antibodies"*
**作者**：Smith J, et al.
**摘要**：开发了一种高特异性SLC17A2单克隆抗体，通过免疫组化证实该蛋白在肾近端小管上皮细胞膜表达，推测其参与尿酸重吸收。
3. **文献名称**：*"SLC17A2 antibody validation for functional studies in neurodegenerative models"*
**作者**：Lee S, et al.
**摘要**：评估了多种SLC17A2抗体的特异性，筛选出适用于Western blot和免疫荧光的抗体，并发现其在阿尔茨海默病模型中表达异常。
(注：实际文献需通过PubMed/Google Scholar等平台检索关键词“SLC17A2 antibody”或“SLC17A2 function”获取。)
The SLC17A2 antibody is a research tool targeting the solute carrier family 17 member 2 (SLC17A2), a transmembrane protein belonging to the SLC17 family of transporters. SLC17A2. also known as vesicular glutamate transporter 2 (VGluT2), primarily facilitates the uptake of glutamate into synaptic vesicles in neurons, playing a critical role in excitatory neurotransmission. However, unlike VGluT1 (SLC17A7) and VGluT3 (SLC17A8), SLC17A2 exhibits broader tissue expression beyond the nervous system, including the kidneys, liver, pancreas, and placenta, suggesting additional roles in cellular metabolism and ion homeostasis.
SLC17A2 antibodies are widely used to study protein localization, expression levels, and functional interactions in both neurological and non-neuronal tissues. They are essential in immunohistochemistry, Western blotting, and immunofluorescence to map SLC17A2 distribution in health and disease. Dysregulation of SLC17A2 has been implicated in metabolic disorders, neurodegenerative diseases, and cancer, making its antibody a valuable tool for exploring disease mechanisms.
Commercially available SLC17A2 antibodies are typically raised in rabbits or mice, targeting specific epitopes within the protein’s cytoplasmic or extracellular domains. Validation often includes knockout controls and tissue-specific expression profiling. Researchers must verify antibody specificity due to potential cross-reactivity with other SLC17 family members. Overall, SLC17A2 antibodies contribute to advancing understanding of glutamate signaling and systemic solute transport processes.
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