| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 771; Mesenchymal stem cell protein DSC43; ZNF771; |
| Entrez GeneID | 51333; |
| WB Predicted band size | 34kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human ZNF771. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF771抗体的3篇参考文献示例(注：部分内容为模拟概括，实际文献可能需要通过数据库进一步检索确认)：
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1. **文献名称**：*ZNF771 is a Prognostic Biomarker in Non-Small Cell Lung Cancer and Regulates Cell Proliferation*
**作者**：Zhang Y, Wang L, et al.
**摘要**：本研究通过免疫组化(IHC)使用ZNF771抗体，发现ZNF771在非小细胞肺癌组织中高表达，且与患者不良预后显著相关。体外实验表明，ZNF771敲低可抑制癌细胞增殖，提示其作为潜在治疗靶点。
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2. **文献名称**：*Epigenetic Regulation of ZNF771 in Neuroblastoma Progression*
**作者**：Lee S, Kim H, et al.
**摘要**：文章利用ZNF771抗体进行Western blot和免疫荧光分析，证实ZNF771在神经母细胞瘤中受DNA甲基化调控。研究显示ZNF771通过调控MYCN信号通路促进肿瘤侵袭，抗体特异性经siRNA敲除实验验证。
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3. **文献名称**：*Development and Validation of a Novel Polyclonal Antibody Against Human ZNF771*
**作者**：Smith J, Patel R, et al.
**摘要**：该文献详细描述了兔源多克隆ZNF771抗体的开发过程，包括抗原设计、免疫印迹(WB)和免疫沉淀(IP)验证。抗体在多种癌症细胞系中检测到ZNF771蛋白表达，并验证其与其他锌指蛋白无交叉反应。
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**提示**：以上文献信息为模拟生成，实际研究中建议通过PubMed、Web of Science或Google Scholar以关键词“ZNF771 antibody”或“ZNF771 protein expression”检索最新文献。部分研究可能未直接使用抗体但涉及ZNF771功能，需结合具体实验目的筛选。
The ZNF771 antibody is a tool used to study the ZNF771 protein, a member of the zinc finger protein (ZFP) family characterized by conserved C2H2-type zinc finger domains. Zinc finger proteins are critical in mediating DNA binding and regulating gene expression, often acting as transcription factors or epigenetic modifiers. ZNF771. though less characterized compared to other ZFPs, is suggested to play roles in transcriptional regulation, potentially influencing cellular processes like proliferation, differentiation, or apoptosis. Its expression has been observed in various tissues, with studies hinting at associations with cancer, neurological disorders, or metabolic diseases, though detailed mechanisms remain under investigation.
The antibody is typically produced in hosts such as rabbits or mice using immunogenic peptides or recombinant protein fragments specific to ZNF771. It is validated for applications like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), or chromatin immunoprecipitation (ChIP) to detect protein expression levels, subcellular localization, or DNA-binding activity. Specificity is often confirmed using knockout cell lines or siRNA-mediated knockdowns. Researchers employ this antibody to explore ZNF771's functional roles in disease models, its interaction partners, or its regulatory targets. Despite its niche focus, the ZNF771 antibody contributes to broader efforts in deciphering the roles of understudied ZFPs in health and disease.
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