Rabbit Polyclonal A20A1 Antibody

The A20A1 antibody is a monoclonal antibody primarily used in biomedical research to detect and study the A20 protein, also known as tumor necrosis factor alpha-induced protein 3 (TNFAIP3). A20 is a critical ubiquitin-editing enzyme that regulates immune and inflammatory responses by modulating nuclear factor-kappa B (NF-κB) signaling pathways. Discovered in the 1990s, A20 acts as a negative feedback regulator, dampening NF-κB activation triggered by cytokines (e.g., TNF-α) or pathogen-associated molecular patterns. Its dysfunction is linked to autoimmune diseases, chronic inflammation, and cancers, particularly B-cell lymphomas. The A20A1 antibody, often generated in mice or rabbits, enables researchers to investigate A20 expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, or immunoprecipitation. Its specificity for A20 helps elucidate mechanisms in disease models, such as how A20 mutations or deletions contribute to uncontrolled inflammation or tumorigenesis. Studies using A20A1 have advanced understanding of A20’s dual roles in apoptosis and cell survival, as well as its therapeutic potential in conditions like rheumatoid arthritis or inflammatory bowel disease. The antibody remains a key tool for exploring A20’s complex regulatory networks in both physiological and pathological contexts.