Rabbit Polyclonal TBPL2 Antibody

The TBPL2 antibody is a research tool designed to detect and study TATA box-binding protein-like 2 (TBPL2), a less characterized member of the TBP family. TBPL2. also known as TRF3 or TBP2. shares structural homology with the well-known TATA-binding protein (TBP), a critical component of the RNA polymerase II transcription initiation complex. Unlike TBP, which is ubiquitously expressed, TBPL2 exhibits tissue-specific expression patterns, predominantly in germ cells, early embryos, and certain somatic tissues. It is proposed to regulate transcription in contexts where TBP is absent or insufficient, such as during gametogenesis or embryogenesis. Studies suggest TBPL2 may participate in specialized transcriptional programs, including oocyte maturation and spermatogenesis, though its precise mechanisms remain under investigation. The TBPL2 antibody enables researchers to visualize protein localization, assess expression levels, and explore its functional roles through techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Its development has been instrumental in uncovering TBPL2's potential involvement in reproductive biology, stem cell regulation, and cancer, where dysregulation has been observed in germ cell tumors and other malignancies. However, commercial availability remains limited, and validation of antibody specificity is crucial due to high sequence similarity within the TBP family.