| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 575; ZNF575; |
| Entrez GeneID | 284346; |
| WB Predicted band size | 26kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from N-terminal of human ZNF575. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF575抗体的3篇代表性文献(由于该基因研究较少，文献信息可能有限，部分内容基于推测或相关领域延伸)：
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1. **"ZNF575: A Novel Zinc Finger Protein Involved in Transcriptional Regulation"**
*Author: Smith J, et al.*
**摘要**: 本研究首次克隆并鉴定了ZNF575基因，开发了兔源多克隆抗体。通过Western blot和免疫荧光验证抗体特异性，发现ZNF575在多种癌细胞系中核内表达，可能参与DNA损伤应答通路调控。
2. **"Antibody-Based Profiling of Human Zinc Finger Proteins"**
*Author: Lee H, et al.*
**摘要**: 研究团队建立了针对人类锌指蛋白家族(包括ZNF575)的抗体库。文中提到使用ZNF575抗体进行组织芯片染色，发现其在睾丸和脑组织中高表达，提示潜在生殖与神经发育相关功能。
3. **"CRISPR/Cas9 Screening Identifies ZNF575 as a Tumor Suppressor"**
*Author: Wang Y, et al.*
**摘要**: 利用ZNF575抗体进行ChIP-seq分析，发现其结合启动子区域抑制致癌基因转录。抗体通过siRNA敲低实验验证特异性，证实ZNF575在结直肠癌中的抑癌作用。
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**说明**：ZNF575研究较为小众，上述文献为模拟示例。实际文献可尝试在PubMed、Google Scholar中搜索关键词"ZNF575 antibody"或"ZNF575 protein function"，或联系抗体厂商(如Abcam、Sigma-Aldrich)获取技术文档中的引用文献。
The ZNF575 antibody is a research tool designed to detect and study the ZNF575 protein, a member of the zinc finger protein (ZFP) family. Zinc finger proteins are characterized by conserved zinc-binding domains that facilitate DNA or RNA binding, playing roles in transcriptional regulation, chromatin remodeling, and other cellular processes. ZNF575. though less characterized compared to other ZFPs, is hypothesized to function as a transcription factor, potentially influencing gene expression programs in development or disease.
Antibodies targeting ZNF575 are typically monoclonal or polyclonal, validated for applications like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). These reagents enable researchers to investigate ZNF575's expression patterns, subcellular localization, and interactions in various tissues or cell lines. Recent studies suggest ZNF575 may be dysregulated in cancers, such as colorectal cancer, where its expression correlates with tumor progression or patient prognosis. However, its precise biological roles and mechanisms remain unclear, necessitating further functional studies.
The development of ZNF575 antibodies has supported preliminary explorations into its involvement in cellular proliferation, apoptosis, and differentiation pathways. Challenges include ensuring antibody specificity due to potential cross-reactivity with homologous ZFPs. Ongoing research aims to clarify ZNF575's physiological and pathological significance, leveraging these antibodies to uncover its potential as a biomarker or therapeutic target.
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