Rabbit Polyclonal NKX28 Antibody

The NKX28 antibody is a specialized tool used in molecular and cellular biology research to detect the NKX28 protein, a member of the NKX family of transcription factors. These proteins are characterized by their conserved homeodomain, which enables DNA binding and regulation of gene expression, particularly during developmental processes. While the functional role of NKX28 remains less extensively studied compared to other family members (e.g., NKX2-1 or NKX2-5), it is hypothesized to participate in tissue-specific development and cellular differentiation, potentially influencing organogenesis or disease pathways. The antibody is typically generated in host species like rabbits or mice using immunogenic peptides derived from conserved regions of the NKX28 protein. It is validated for applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to determine protein expression patterns in biological samples. Researchers employ this reagent to explore NKX28's localization, expression levels under varying conditions (e.g., disease states), and interactions with downstream targets. Its specificity is often confirmed via knockout controls or siRNA-mediated silencing. NKX28 antibodies contribute to studies in developmental biology, oncology, and regenerative medicine, though further characterization of the protein's biological significance remains an active area of investigation.