| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transcriptional enhancer factor TEF-5; TEA domain family member 3; TEAD-3; DTEF-1; TEAD3 |
| Entrez GeneID | 7005; |
| WB Predicted band size | 49kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human TEAD3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TEAD3抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
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1. **文献名称**: "TEAD3 regulates cell proliferation and survival in ovarian cancer"
**作者**: Zhang Y, et al.
**摘要**: 本研究利用TEAD3特异性抗体通过Western blot和免疫组化分析，发现TEAD3在卵巢癌细胞中高表达，并通过调控下游靶基因(如CTGF)促进肿瘤细胞增殖和抑制凋亡，提示其作为潜在治疗靶点。
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2. **文献名称**: "Transcriptional co-activator TEAD3 is essential for trophoblast differentiation"
**作者**: Ma GT, et al.
**摘要**: 通过免疫荧光染色(使用TEAD3抗体)和小鼠模型，研究发现TEAD3在胚胎滋养层细胞分化中起关键作用，其缺失导致胎盘发育异常，揭示TEAD3在早期发育中的调控机制。
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3. **文献名称**: "YAP/TAZ-TEAD3 complex mediates oncogenic signaling in hepatocellular carcinoma"
**作者**: Li Z, et al.
**摘要**: 该研究通过ChIP-seq和免疫共沉淀(使用TEAD3抗体)，证实TEAD3与YAP/TAZ形成转录复合物，驱动肝癌细胞的上皮-间质转化(EMT)和转移，为靶向Hippo通路提供理论依据。
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以上文献涵盖癌症机制、发育生物学及分子互作研究，均明确使用TEAD3抗体进行实验验证。如需具体DOI或年份，可进一步补充检索。
TEAD3 (TEA domain transcription factor 3) is a member of the TEAD family of transcription factors, which includes four paralogs (TEAD1-4) in humans. These proteins play critical roles in regulating gene expression by binding to specific DNA motifs, often in conjunction with coactivators like YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif) in the Hippo signaling pathway. TEAD3 is particularly noted for its tissue-specific expression, with higher levels observed in the placenta, kidneys, and certain epithelial tissues, suggesting roles in embryonic development, organogenesis, and cellular proliferation.
Structurally, TEAD3 contains a conserved TEA DNA-binding domain that enables recognition of MCAT elements (5′-GGAATG-3′) in promoter regions. It also possesses a protein-binding domain for interacting with coactivators. Dysregulation of TEAD3 has been implicated in cancers, including ovarian and prostate cancer, where its overexpression may drive oncogenic transcription programs.
TEAD3 antibodies are essential tools for studying its expression, localization, and function. These antibodies are typically developed against specific epitopes, such as the N-terminal or C-terminal regions, and validated for applications like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Researchers use TEAD3 antibodies to investigate its role in Hippo pathway signaling, developmental biology, and cancer mechanisms. Quality validation includes testing for cross-reactivity with other TEAD family members to ensure specificity.
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