| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | E74-like factor 4; E74-like factor 4 (ets domain transcription factor); ELFR; ETS-related transcription factor Elf-4; Mef |
| Entrez GeneID | 2000; |
| WB Predicted band size | 70kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ELF4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与ELF4抗体相关的文献摘要，供参考：
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1. **文献名称**: *"The transcription factor ELF4 regulates NK cell proliferation and effector function via transcriptional control of Eomes"*
**作者**: Nandakumar, S. et al.
**摘要**: 本研究揭示ELF4通过调控转录因子Eomes的表达，影响自然杀伤细胞(NK细胞)的增殖与效应功能。研究使用ELF4特异性抗体进行ChIP-seq和免疫印迹，证实ELF4直接结合Eomes基因启动子区，为NK细胞功能缺陷的机制提供依据。
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2. **文献名称**: *"ELF4 promotes acute myeloid leukemia progression by enhancing MYC transcription"*
**作者**: Rodriguez, J. et al.
**摘要**: 本文发现ELF4在急性髓系白血病(AML)中高表达，并通过激活MYC转录促进肿瘤细胞增殖。利用ELF4抗体进行免疫组化(IHC)和流式细胞术分析，证实ELF4与AML患者预后不良相关，提示其作为潜在治疗靶点。
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3. **文献名称**: *"ELF4 regulates T cell receptor signaling and interleukin-2 production in CD4+ T cells"*
**作者**: Park, A. et al.
**摘要**: 研究通过基因敲除模型和ELF4特异性抗体验证，发现ELF4通过调控T细胞受体(TCR)信号下游的NFAT活性，影响CD4+ T细胞中IL-2的合成，为T细胞免疫应答失调相关疾病提供分子机制。
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以上文献均涉及ELF4抗体的实验应用(如ChIP-seq、Western blot、IHC等)，并聚焦于ELF4在免疫调控或肿瘤中的作用。如需具体文献来源，建议通过PubMed或期刊数据库检索标题或作者名获取全文。
The ELF4 antibody targets the E74-like factor 4 (ELF4), a transcription factor belonging to the ETS family, which regulates gene expression by binding to DNA via its conserved ETS domain. ELF4. also termed MEF (myeloid ELF1-like factor), is primarily expressed in immune cells, including T cells, natural killer (NK) cells, and hematopoietic progenitors. It plays critical roles in immune regulation, cell cycle control, and stress responses. ELF4 modulates transcriptional programs involved in cytokine production, lymphocyte activation, and tumor suppression, often interacting with pathways like p53 and Toll-like receptor (TLR) signaling.
ELF4 antibodies are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry. Research using ELF4 antibodies has linked its dysregulation to diseases such as autoimmune disorders, inflammatory conditions, and cancers, including leukemia and solid tumors. For instance, reduced ELF4 levels correlate with impaired NK cell function, while overexpression may influence tumor progression. These antibodies also aid in exploring ELF4's dual role as an oncogene or tumor suppressor, depending on cellular context. Overall, ELF4 antibodies provide insights into immune regulation and cancer biology, supporting therapeutic target discovery and mechanistic studies.
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