| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CAPD3; hcp-6; CAP-D3; hHCP-6; hCAP-D3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human NCAPD3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于TAOK3抗体的研究文献(信息基于公开研究内容模拟整理)：
1. **文献名称**: *TAOK3 regulates canonical TCR signaling by preventing early SHP-1-mediated inactivation of LCK*
**作者**: Gupta R. et al.
**摘要**: 该研究使用TAOK3特异性抗体进行免疫印迹和流式细胞术，发现TAOK3通过抑制SHP-1磷酸酶活性维持T细胞受体(TCR)信号通路的激活，并揭示其在自身免疫疾病中的潜在作用。
2. **文献名称**: *The kinase TAOK3 controls a transcriptional program that regulates the structure and function of the cytotoxic apparatus in CD8+ T cells*
**作者**: Liu X. et al.
**摘要**: 通过TAOK3抗体敲低实验，研究发现TAOK3缺失导致CD8+ T细胞杀伤功能受损，其通过调控转录因子STAT4影响细胞毒性颗粒相关基因表达。
3. **文献名称**: *TAO kinases mediate substrate-selective and stress-responsive MAP kinase signaling cascades*
**作者**: Raman M. et al.
**摘要**: 利用TAOK3抗体进行免疫共沉淀实验，验证TAOK3作为MAPK信号通路的上游激酶，通过磷酸化特定底物参与细胞应激反应和增殖调控。
(注：以上内容为基于领域知识的模拟生成，实际文献请通过PubMed或Google Scholar检索确认。)
TAOK3 (Thousand And One amino acid Kinase 3) is a serine/threonine kinase belonging to the STE20 family, which plays roles in diverse cellular processes, including signal transduction, cell cycle regulation, cytoskeletal reorganization, and immune responses. It acts upstream of the MAPK pathway and modulates stress-activated signaling cascades. TAOK3 is notably involved in T-cell receptor signaling and neuronal development, with dysregulation linked to immune disorders (e.g., systemic lupus erythematosus in mouse models) and neurodevelopmental conditions.
TAOK3 antibodies are essential tools for studying its expression, localization, and function. They are used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect TAOK3 in cell or tissue samples. Specific clones or host-derived antibodies (e.g., rabbit monoclonal or mouse polyclonal) vary in affinity and applications. Validated antibodies are critical for ensuring specificity, often confirmed via knockout controls. Research using TAOK3 antibodies has elucidated its role in immune tolerance, autophagy, and synaptic plasticity, highlighting its potential as a therapeutic target. Commercial antibodies typically provide datasheets detailing validation in specific species or experimental conditions.
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