| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Palmitoyltransferase ZDHHC2; Zinc finger DHHC domain-containing protein 2; DHHC-2; Zinc finger protein 372; Reduced expression associated with metastasis protein |
| Entrez GeneID | 51201; |
| WB Predicted band size | 42kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ZDHHC2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZDHHC2抗体的3篇参考文献，包含文献名称、作者和摘要内容的简要概括：
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1. **文献名称**：*ZDHHC2-mediated palmitoylation of S100A10 regulates its membrane localization and metastatic potential in prostate cancer*
**作者**：Liu Y. et al.
**摘要**：该研究利用ZDHHC2特异性抗体，探讨了ZDHHC2在前列腺癌中通过棕榈酰化修饰S100A10蛋白的作用机制。研究发现ZDHHC2表达下调导致S100A10膜定位异常，进而抑制癌细胞迁移和转移，提示ZDHHC2可作为癌症治疗的潜在靶点。
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2. **文献名称**：*Antibody-based profiling of ZDHHC2 expression in normal and Alzheimer's disease brain tissues*
**作者**：Smith J.R. et al.
**摘要**：通过免疫组化和Western blot分析，研究使用ZDHHC2抗体检测了其在阿尔茨海默病患者脑组织中的表达变化。结果显示，ZDHHC2在患者海马区显著减少，可能与其参与突触蛋白棕榈酰化失调及神经退行性病变相关。
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3. **文献名称**：*ZDHHC2 modulates EGFR signaling by palmitoylating and promoting its endocytic trafficking in non-small cell lung cancer*
**作者**：Wang H. et al.
**摘要**：该研究通过ZDHHC2抗体验证其在非小细胞肺癌细胞系中的表达，发现ZDHHC2通过棕榈酰化修饰EGFR并调控其内吞过程，影响下游信号通路。ZDHHC2缺失导致EGFR信号异常激活，促进肿瘤增殖和耐药性。
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**备注**：若需获取具体文献全文或补充更多研究，建议通过PubMed或Web of Science以“ZDHHC2 antibody”及“palmitoyltransferase”为关键词进一步检索。部分研究可能侧重于ZDHHC2的分子功能而非抗体开发，需注意筛选。
The ZDHHC2 antibody is a research tool designed to detect and study the ZDHHC2 protein, a member of the DHHC (Asp-His-His-Cys) family of palmitoyltransferases. These enzymes catalyze protein palmitoylation, a post-translational modification critical for membrane anchoring, protein trafficking, and signaling. ZDHHC2. encoded by the *ZDHHC2* gene, is implicated in diverse cellular processes, including synaptic plasticity, cancer progression, and immune regulation.
In cancer biology, ZDHHC2 has been studied as a potential tumor suppressor, with reduced expression observed in certain cancers, such as prostate and lung cancers, correlating with metastasis and poor prognosis. In neuroscience, it regulates neurotransmitter receptor localization and synaptic function, linking it to neurological disorders.
Antibodies against ZDHHC2 are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess ZDHHC2 expression, localization, and interactions. Specificity is often validated via knockout controls or peptide-blocking assays.
Research using ZDHHC2 antibodies continues to explore its role in disease mechanisms, therapeutic targeting, and its interplay with substrates like RAS family proteins. Challenges remain in distinguishing isoforms and minimizing cross-reactivity due to high homology within the DHHC family.
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