关键信息
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基因名
GDN
- 应用
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别名
GDN；PI7；PN1；Glia-derived nexin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P07093
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表达区间
20-398aa
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氨基酸序列
SHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP
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分子量
57.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GDN (Glial cell line-derived neurotrophic factor) is a crucial neurotrophic factor known for its role in the survival, differentiation, and maintenance of various neuronal populations. Research into GDN has gained momentum due to its potential therapeutic implications in neurodegenerative diseases, such as Parkinson's disease, Alzheimer’s disease, and amyotrophic lateral sclerosis. Studies have demonstrated that GDN exerts protective effects on dopaminergic neurons and promotes neurogenesis, making it a target of interest for novel treatment strategies. Furthermore, GDN's ability to modulate glial cell activity highlights its significance in the neuroinflammatory response, a critical aspect in various neurological disorders. Advances in recombinant protein technology have enabled the production of GDN in a more efficient and scalable manner, facilitating extensive research into its properties and mechanisms of action. This includes exploring the optimal delivery methods for GDN in vivo, examining its interactions with specific receptors, and assessing its long-term effects on neuronal pathways. As research progresses, understanding the intricate role of GDN in neuronal health and pathology could pave the way for developing innovative therapeutic approaches aimed at alleviating the burdens of neurodegenerative diseases and enhancing neuronal repair and regeneration.
