| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ARP1; CTRN1 |
| Entrez GeneID | 10121; |
| WB Predicted band size | 43kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Fusion protein corresponding to residues near the C terminal of human ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ACTR1A抗体的3篇参考文献(信息基于公开研究整合，非真实文献，仅供示例参考)：
1. **文献名称**: *"ACTR1A regulates microtubule stability in neuronal development"*
**作者**: Smith J, et al.
**摘要**: 研究通过ACTR1A特异性抗体，揭示了其在神经元轴突形成中通过稳定微管结构调控突触可塑性的机制，证实了ACTR1A与动力蛋白复合体的功能关联。
2. **文献名称**: *"Proteomic analysis of ACTR1A in cancer cell migration"*
**作者**: Lee S, et al.
**摘要**: 利用ACTR1A抗体进行免疫沉淀和质谱分析，发现其与细胞迁移相关蛋白(如Cortactin)的相互作用，提示ACTR1A在肿瘤转移中的潜在作用。
3. **文献名称**: *"ACTR1A antibody validation for diagnostic applications"*
**作者**: Wang Y, et al.
**摘要**: 系统性验证了多种ACTR1A抗体的特异性，建立了一种基于该抗体的免疫组化方法，用于检测卵巢癌组织中ACTR1A的表达异常，并与患者预后相关。
注：以上为模拟内容，实际文献需通过学术数据库检索获取。
The ACTR1A antibody targets the ACTR1A protein (also known as ARP1 or Centractin), a member of the actin-related protein (ARP) family. ACTR1A plays a critical role in cellular processes such as vesicle transport, cell motility, and cytokinesis by interacting with the cytoskeleton, particularly microtubules. It is a key component of the dynactin complex, which associates with dynein motors to facilitate retrograde transport of organelles and vesicles along microtubules.
ACTR1A antibodies are widely used in research to study its expression, localization, and function in diverse cell types. They are essential tools in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate cytoskeletal dynamics, intracellular trafficking, and centrosome organization. Dysregulation of ACTR1A has been implicated in neurological disorders, developmental defects, and cancers, making its antibody valuable for exploring disease mechanisms.
Structurally, ACTR1A shares homology with actin but lacks filament-forming activity. Its antibody specificity helps distinguish it from other ARP family members (e.g., ACTR1B). Studies using ACTR1A antibodies have also elucidated its role in γ-tubulin ring complex (γ-TuRC) assembly during microtubule nucleation. Available as monoclonal or polyclonal variants, these antibodies are optimized for cross-reactivity in human, mouse, and rat models, supporting translational and basic research.
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