| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MUTED-TXNDC5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TXNDC5抗体的3篇文献示例(注：内容为虚构，仅作格式参考)：
1. **"TXNDC5 promotes colorectal cancer metastasis by enhancing angiogenesis through redox-sensitive signaling pathways"**
- 作者：Li, X.; Zhang, Y.; et al.
- 摘要：研究通过免疫组化(使用TXNDC5抗体)发现其在结直肠癌组织中高表达，并通过调控VEGF信号通路促进肿瘤血管生成，机制涉及ROS依赖的HIF-1α活化。
2. **"TXNDC5 antibody-based detection reveals its role in hepatocellular carcinoma progression via ER stress modulation"**
- 作者：Wang, H.; Chen, J.; et al.
- 摘要：利用TXNDC5抗体进行Western blot和免疫荧光分析，证实TXNDC5通过激活内质网应激相关蛋白(如GRP78)驱动肝细胞癌增殖和化疗耐药。
3. **"TXNDC5 as a novel biomarker in atherosclerosis: Insights from endothelial cell-specific knockout models"**
- 作者：Kim, S.; Park, M.; et al.
- 摘要：研究使用TXNDC5抗体检测动脉粥样硬化斑块中的蛋白表达，发现其通过NF-κB通路加剧内皮炎症反应，敲除后显著减轻小鼠模型病变。
(提示：实际文献需通过PubMed等数据库以“TXNDC5 antibody”为关键词检索获取。)
The TXNDC5 (Thioredoxin Domain-Containing 5) antibody is a critical tool for studying the role of TXNDC5. a protein belonging to the thioredoxin family known for regulating redox homeostasis. TXNDC5 contains a conserved thioredoxin-like domain and is primarily localized in the endoplasmic reticulum (ER). It participates in protein folding, disulfide bond formation, and ER stress response by interacting with other oxidoreductases. Dysregulation of TXNDC5 has been linked to pathological conditions, including cancer, cardiovascular diseases, and fibrosis. For instance, it promotes cancer cell proliferation, metastasis, and chemoresistance in colorectal, breast, and liver cancers by modulating pathways like VEGF signaling and EMT (epithelial-mesenchymal transition). In cardiovascular contexts, TXNDC5 is implicated in endothelial dysfunction and atherosclerosis.
TXNDC5 antibodies, often generated in hosts like rabbits or mice, enable detection and quantification of the protein via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. These antibodies are essential for exploring TXNDC5’s expression patterns, post-translational modifications, and interactions in disease models. Validated antibodies with high specificity are crucial, as off-target binding can confound results. Recent studies highlight TXNDC5’s potential as a therapeutic target or biomarker, driving demand for reliable antibodies. However, challenges remain in standardizing antibody performance across experimental conditions. Ongoing research aims to clarify TXNDC5’s mechanistic roles and evaluate its clinical relevance, underscoring the antibody’s importance in both basic and translational studies.
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