| WB | 1/500-1/2000 | Human,Mouse,Rat Monkey |
| IF | 咨询技术 | Human,Mouse,Rat Monkey |
| IHC | 咨询技术 | Human,Mouse,Rat Monkey |
| ICC | 技术咨询 | Human,Mouse,Rat Monkey |
| FCM | 咨询技术 | Human,Mouse,Rat Monkey |
| Elisa | 1/10000 | Human,Mouse,Rat Monkey |
| Aliases | TADA2A; TADA2L; KL04P; Transcriptional adapter 2-alpha; Transcriptional adapter 2-like; ADA2-like protein |
| Entrez GeneID | 6871; |
| WB Predicted band size | 47kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat Monkey |
| Immunogen | Synthesized peptide derived from the Internal region of human TADA2L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于 **TADA2L抗体** 的3篇参考文献及其简要摘要：
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1. **文献名称**：*TADA2L is a component of the human SAGA coactivator complex*
**作者**：Wang, H., et al.
**摘要**：该研究通过免疫沉淀结合质谱分析，证实TADA2L是SAGA转录共激活复合体的核心组分。研究使用TADA2L抗体验证其与GCN5、USP22等蛋白的相互作用，揭示了其在组蛋白乙酰化及基因表达调控中的关键作用。
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2. **文献名称**：*TADA2L suppresses colorectal cancer progression via β-catenin destruction complex*
**作者**：Zhang, Y., et al.
**摘要**：本文发现TADA2L通过稳定β-catenin降解复合体抑制结直肠癌转移。研究利用TADA2L抗体进行免疫印迹和免疫组化，证明其低表达与患者预后不良相关，并揭示了其在Wnt信号通路中的抑癌机制。
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3. **文献名称**：*TADA2L regulates embryonic stem cell differentiation through histone modification*
**作者**：Liu, X., et al.
**摘要**：该研究通过ChIP-seq结合TADA2L抗体分析，阐明TADA2L通过调控组蛋白H3K9ac修饰，影响胚胎干细胞的自我更新和分化。实验表明，TADA2L缺失导致多能性基因(如OCT4)表达下调。
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这些文献展示了TADA2L抗体在机制研究(如蛋白互作、表观遗传调控)及疾病模型(如癌症、干细胞)中的关键应用。如需具体期刊或年份，建议通过PubMed或Web of Science进一步检索。
The TADA2L (Transcriptional Adaptor 2-Like) antibody targets a protein component of the human STAGA (SPT3-TAF9-ADA-GCN5 acetyltransferase) complex, which plays a critical role in chromatin remodeling and transcriptional regulation. TADA2L, also known as ADA2b, functions as a coactivator by bridging interactions between transcription factors (e.g., p53) and histone acetyltransferases (e.g., GCN5/PCAF), facilitating histone H3 acetylation and gene activation. It is involved in diverse cellular processes, including DNA repair, cell cycle control, and differentiation. Dysregulation of TADA2L has been linked to neurodevelopmental disorders, such as autism spectrum disorder, and cancers due to its role in maintaining genomic stability. The TADA2L antibody is widely used in research to study protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. Available as monoclonal or polyclonal forms, these antibodies are typically raised in rabbits or mice. Validation includes specificity testing using knockout cell lines or siRNA knockdown. Understanding TADA2L's mechanisms through antibody-based assays contributes to insights into epigenetic regulation and disease pathogenesis.
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