Cat: PA2000-805DB

Recombinant Human ABCA2 Protein,His

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关键信息

  • 基因名

    ABCA2

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    ABCA2;ABC2;KIAA1062;ATP-binding cassette sub-family A member 2

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    Q9BZC7

  • 表达区间

    全长

  • 氨基酸序列

    full

  • 分子量

    269.8 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

ABCA2 (ATP-binding cassette sub-family A member 2) is a member of the ATP-binding cassette (ABC) transporter family, which plays a crucial role in the transport of various molecules across cellular membranes. Research into ABCA2 has gained prominence due to its involvement in several physiological processes and pathological conditions, including lipid metabolism, neurological function, and the immune response. Notably, ABCA2 is expressed in the brain and has been linked to neurodegenerative diseases, suggesting its potential role in cellular homeostasis and the clearance of toxic metabolites. Studies have shown that ABCA2 may influence cholesterol transport and modulate the risk for conditions such as Alzheimer's disease. Moreover, the protein has been identified in immune cells, indicating a broader role in immune system functionality. To further elucidate the mechanisms by which ABCA2 operates and its contributions to health and disease, researchers are increasingly focusing on the expression, function, and regulation of this protein. Recombinant ABCA2 protein, produced using modern biotechnological methods, serves as a valuable tool for studying its structural and biochemical properties. Understanding how ABCA2 interacts with various substrates and its functional implications could lead to novel therapeutic approaches in managing diseases associated with ABCA2 dysfunction. Overall, the study of ABCA2 recombined protein represents a promising frontier in both molecular biology and potential clinical applications, aiming to unlock solutions for complex health issues stemming from its dysregulation.

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