| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ARMC2 |
| Uniprot No | Q8NEN0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-860aa |
| 氨基酸序列 | MLGKLDPFYQPSVSKQKTSAEIISEARNALRTVRTQRPFTPQEAQRKLFGPASSRTSENRPPSSFSLHASSFESSDSRPISGTRLSPLELKPKVPASPTREEDSCFSFPKPPVDPAKIRRVSNARARLFRAASQRALLPDRSLPPSDSKKTVESKETVMMGDSMVKINGIYLTKSNAICHLKSHPLQLTDDGGFSEIKEQEMFKGTTSLPSHLKNGGDQGKRHARASSCPSSSDLSRLQTKAVPKADLQEEDAEIEVDEVFWNTRIVPILRELEKEENIETVCAACTQLHHALEEGNMLGNKFKGRSILLKTLCKLVDVGSDSLSLKLAKIILALKVSRKNLLNVCKLIFKISRNEKNDSLIQNDSILESLLEVLRSEDLQTNMEAFLYCMGSIKFISGNLGFLNEMISKGAVEILINLIKQINEDIKKCGTFLPNSGHLLVQVTATLRNLVDSSLVRSKFLNISALPQLCTAMEQYKGDKDVCTNIARIFSKLTSYRDCCTALASYSRCYALFLNLINKYQKKQDLVVRVVFILGNLTAKNNQAREQFSKEKGSIQTLLSLFQTFHQLDLHSQKPVGQRGEQHRAQRPPSEAEDVLIKLTRVLANIAIHPGVGPVLAANPGIVGLLLTTLEYKSLDDCEELVINATATINNLSYYQVKNSIIQDKKLYIAELLLKLLVSNNMDGILEAVRVFGNLSQDHDVCDFIVQNNVHRFMMALLDAQHQDICFSACGVLLNLTVDKDKRVILKEGGGIKKLVDCLRDLGPTDWQLACLVCKTLWNFSENITNASSCFGNEDTNTLLLLLSSFLDEELALDGSFDPDLKNYHKLHWETEFKPVAQQLLNRIQRHHTFLEPLPIPSF |
| 分子量 | 122.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于ARMC2的假想参考文献示例(仅供格式参考，实际文献需通过学术数据库验证)：
1. **"ARMC2 is essential for sperm motility and male fertility in mice"**
- 作者：Suriagandhi V et al. (2022)
- 摘要：首次发现ARMC2在小鼠睾丸中高表达，通过基因敲除实验证明其缺失导致精子鞭毛结构异常和运动能力丧失，提示其在男性不育中的作用。
2. **"ARMC2 interacts with kinesin proteins to regulate ciliary assembly"**
- 作者：Tian Y et al. (2020)
- 摘要：通过免疫共沉淀实验揭示ARMC2与驱动蛋白KIF3A/3B的相互作用，调控纤毛微管结构的形成，影响细胞信号转导。
3. **"ARMC2 mutations in primary ciliary dyskinesia patients"**
- 作者：Lorente-Cánovas B et al. (2023)
- 摘要：临床研究发现ARMC2基因突变与原发性纤毛运动障碍(PCD)相关，患者表现为慢性呼吸道感染和精子运动异常。
**注意**：以上为模拟文献，实际研究中建议通过PubMed、Google Scholar等平台以“ARMC2”、“armadillo repeat protein”为关键词检索最新论文。真实研究多聚焦于ARMC2在纤毛功能、生殖发育及癌症中的分子机制。
**Armadillo Repeat-Containing Protein 2 (ARMC2)** is a member of the ARMC protein family, characterized by multiple armadillo (ARM) repeat domains that facilitate protein-protein interactions. Though ARMC proteins are implicated in diverse cellular processes, including cytoskeletal organization, signaling, and intracellular transport, the precise biological role of ARMC2 remains understudied.
ARMC2 is primarily expressed in testicular tissues and has been linked to male fertility. Research in murine models demonstrates that ARMC2 knockout leads to male infertility due to defects in sperm flagellum formation and motility. Specifically, ARMC2 appears critical for mitochondrial sheath assembly during spermatogenesis, a process essential for providing energy to sperm. Structural disruptions in ARMC2-deficient sperm result in impaired mitochondrial organization and compromised sperm movement.
Beyond reproduction, ARMC2 may interact with signaling pathways, such as Wnt or TGF-β, though mechanistic details are unclear. Mutations or dysregulation of ARMC2 have also been tentatively associated with ciliopathies and metabolic disorders, hinting at broader physiological roles. However, its molecular partners, regulatory mechanisms, and disease-related implications require further exploration.
As an emerging focus in reproductive and cellular biology, ARMC2 represents a potential biomarker or therapeutic target for male infertility. Current studies emphasize unraveling its structural-functional relationships and tissue-specific activities to bridge gaps in understanding its contribution to development and disease.
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