Recombinant Human C17orf35 Protein

The human protein encoded by the *C17orf35* gene (Chromosome 17 Open Reading Frame 35), also termed C17orf35 or FAM231B, is a poorly characterized protein with limited functional annotation. It resides on chromosome 17q12. a genomic region associated with cancer susceptibility and other diseases, though its precise biological role remains unclear. The gene encodes a hypothetical protein of approximately 18 kDa, predicted to contain conserved motifs suggesting potential involvement in protein-protein interactions or nucleic acid binding. Recombinant C17orf35 protein is typically expressed in heterologous systems (e.g., *E. coli* or mammalian cells) for functional studies, enabling antibody production, structural analysis, and interaction mapping.

Current studies indicate low baseline expression in most tissues, with upregulated levels observed in certain cancers, including breast and prostate tumors, hinting at a possible context-dependent role in cell proliferation or stress responses. In silico analyses propose post-translational modification sites (e.g., phosphorylation) and a putative nuclear localization signal, though experimental validation is lacking. Its evolutionary conservation across vertebrates suggests essential but undiscovered functions. Research efforts focus on clarifying its interaction networks, subcellular localization, and potential links to 17q12-associated pathologies. Further proteomic and transcriptomic profiling is required to define its physiological and pathological significance.