Recombinant Human CCDC132 Protein

Coiled-coil domain-containing protein 132 (CCDC132) is a relatively understudied protein encoded by the *CCDC132* gene in humans, located on chromosome 7q31.32. Structurally, it is characterized by multiple coiled-coil domains, which mediate protein-protein interactions, suggesting a role in scaffolding or assembling multi-protein complexes. The protein is ubiquitously expressed across tissues, with higher levels observed in the brain, testis, and thyroid. While its precise biological functions remain unclear, emerging studies link CCDC132 to cellular processes such as intracellular trafficking, microtubule dynamics, and possibly mitosis. Proteomic analyses have identified interactions with components of the dynein-dynactin motor complex and microtubule-associated proteins, implicating it in organelle transport or cytoskeletal organization. Dysregulation of CCDC132 has been tentatively associated with cancers, including prostate and thyroid malignancies, though mechanistic insights are limited. Additionally, rare genetic variants in *CCDC132* have been reported in neurological disorders, hinting at potential neurodevelopmental roles. Current research gaps include a lack of *in vivo* functional validation, unclear signaling pathways, and undefined connections to disease pathogenesis. Further studies are needed to elucidate its molecular mechanisms, post-translational modifications, and therapeutic relevance.