关键信息
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基因名
KAT2B
- 应用
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别名
KAT2B；PCAF；Histone acetyltransferase KAT2B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92831
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表达区间
431-832aa
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氨基酸序列
MTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSA RDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMP KEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNE QVKGYGTHLMNHLKEYHIKHDILNFLTYADEYAIGYFKKQGFSKEIKIPK TKYVGYIKDYEGATLMGCELNPRIPYTEFSVIIKKQKEIIKKLIERKQAQ IRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSKEPRDPDQLYS TLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNR YYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLI DK
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分子量
70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
KAT2B, also known as LYSINE ACETYLTRANSFERASE 2B, is a member of the GCN5-related N-acetyltransferase (GNAT) family, which plays a crucial role in the post-translational modification of proteins through acetylation. This modification affects various cellular processes, including gene expression, cellular metabolism, and signal transduction. KAT2B has garnered attention for its involvement in several physiological and pathological conditions, such as cancer, metabolic disorders, and neurodegenerative diseases. Research has shown that KAT2B influences the transcriptional regulation of key genes by modifying histones and non-histone proteins, thereby impacting chromatin structure and function. Investigating KAT2B's role in these processes is vital for understanding the underlying mechanisms of diseases and developing potential therapeutic strategies. Recent advancements in recombinant protein technology have facilitated the production of KAT2B, allowing researchers to explore its structure, function, and interactions with other proteins. This research may lead to significant insights into the regulatory networks governed by acetylation and provide new avenues for drug discovery and development in treating disorders linked to dysregulated acetylation.
