关键信息
-
基因名
TGFBR2
- 应用
-
别名
TGFBR2；ALK5；TGF-beta receptor type-1
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P37173
-
表达区间
23-166aa
-
氨基酸序列
TIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQ
-
分子量
23.8 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Transforming Growth Factor Beta Receptor II (TGFBR2) is a key component of the TGF-β signaling pathway, which plays an essential role in regulating various cellular processes, including cell proliferation, differentiation, apoptosis, and immune response. Abnormalities in this pathway have been implicated in a range of diseases, including cancer, fibrosis, and hereditary syndromes such as Marfan and Loeys-Dietz syndromes. Research into TGFBR2 has intensified due to its potential as a therapeutic target; however, the lack of available recombinant protein has hindered functional studies. Recombinant TGFBR2 protein production allows scientists to better understand its structure, function, and interactions with ligands and other proteins, facilitating the development of targeted therapies. By elucidating TGFBR2's role in disease mechanisms, researchers aim to identify novel biomarkers for diagnosis and prognosis, as well as to create strategies for intervention that mitigate the adverse effects of TGF-β signaling dysregulation. Hence, the production and characterization of TGFBR2 recombinant protein is essential for advancing our knowledge in molecular biology and pharmacology, ultimately contributing to improved health outcomes.
