| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAIM2 |
| Uniprot No | Q9BWQ8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-316aa |
| 氨基酸序列 | MTQGKLSVANKAPGTEGQQQVHGEKKEAPAVPSAPPSYEEATSGEGMKAGAFPPAPTAVPLHPSWAYVDPSSSSSYDNGFPTGDHELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVLFVLLMTLFFSGLILAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE |
| 分子量 | 60.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人FAIM2蛋白的3篇代表性文献(虚构示例，仅供参考)：
1. **文献名称**：**"FAIM2: A novel neuronal apoptosis inhibitor modulating Fas-mediated cell death"**
**作者**：Seguí R, et al.
**摘要**：该研究首次克隆并表达了重组人FAIM2蛋白，证实其通过抑制Fas受体信号通路抵抗神经元凋亡，为神经退行性疾病机制提供了新见解。
2. **文献名称**：**"Expression and functional characterization of recombinant human FAIM2 in neuroprotection"**
**作者**：Díez H, et al.
**摘要**：研究者在大肠杆菌系统中高效表达并纯化了重组FAIM2蛋白，发现其可阻断FasL诱导的神经元凋亡，提示其在神经保护中的潜在应用。
3. **文献名称**：**"Structural insights into FAIM2-mediated inhibition of apoptosis by X-ray crystallography"**
**作者**：Zhou Y, et al.
**摘要**：通过重组FAIM2蛋白的结晶结构分析，揭示了其与Fas受体互作的关键结构域，阐明了其抗凋亡的分子机制。
(注：以上文献名称及作者为假设示例，实际研究中请通过数据库如PubMed或Web of Science验证具体文献。)
Recombinant human FAIM2 (Fas Apoptosis Inhibitory Molecule 2) protein is a key regulator of cell survival and apoptosis. FAIM2. also known as Lifeguard (LFG), is a transmembrane protein predominantly expressed in the nervous system. It inhibits Fas-mediated apoptosis by interacting with the Fas receptor, thereby blocking the formation of the death-inducing signaling complex (DISC). Unlike other apoptosis inhibitors like FLIP, FAIM2 specifically targets the extrinsic apoptotic pathway, playing a critical role in neuronal development and protection against neurotoxicity. Studies suggest its involvement in neurodegenerative diseases, such as Alzheimer's and Parkinson’s, where apoptosis dysregulation contributes to pathogenesis. Recombinant FAIM2 proteins, typically produced in mammalian expression systems (e.g., HEK293 or CHO cells), retain functional domains necessary for binding Fas and modulating apoptotic signals. These proteins serve as essential tools for dissecting FAIM2's molecular mechanisms, screening therapeutic agents, and exploring its potential as a neuroprotective target. Current research focuses on clarifying its signaling crosstalk, post-translational modifications, and tissue-specific roles. The development of recombinant FAIM2 also opens avenues for therapeutic strategies aiming to enhance neuronal survival or treat apoptosis-related disorders.
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