Recombinant Human FLJ22167 Protein

Recombinant human FLJ22167 protein is a genetically engineered form of the FLJ22167 protein encoded by the human gene FLJ22167 (also known as C1orf115 or Chromosome 1 Open Reading Frame 115). This gene, located on chromosome 1 (1p36.33), encodes a protein of uncertain function, though bioinformatics analyses suggest potential involvement in cellular processes such as protein binding, signal transduction, or metabolic regulation. The FLJ22167 protein is predicted to contain multiple structural domains, including a conserved UPF0196 domain, which is found in proteins of diverse organisms but remains poorly characterized.

Recombinant FLJ22167 is typically produced using heterologous expression systems (e.g., E. coli, mammalian cells) to enable functional studies. Its recombinant form often includes tags (e.g., His-tag) for purification and detection. Despite limited functional data, FLJ22167 has been linked to diseases through genomic association studies, including potential roles in cancer progression and neurological disorders. For example, altered expression has been observed in certain tumors, suggesting possible involvement in cell proliferation or apoptosis. Research on this protein remains preliminary, with current efforts focusing on elucidating its interactome, subcellular localization, and enzymatic activities. Its recombinant version serves as a critical tool for antibody development, structural studies, and pathway analysis, aiming to uncover its biological significance and therapeutic potential. Further studies are needed to clarify its molecular mechanisms and validate hypothesized roles in health and disease.