| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | GAS2L2 |
| Uniprot No | Q8NHY3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-880aa |
| 氨基酸序列 | MSQPAGGRRKPRTLGPPVCSIRPFKSSEQYLEAMKEDLAEWLRDLYGLDIDAANFLQVLETGLVLCQHANVVTDAALAFLAEAPAQAQKIPMPRVGVSCNGAAQPGTFQARDNVSNFIQWCRKEMGIQEVLMFETEDLVLRKNVKNVVLCLLELGRRAWRFGVAAPTLVQLEEEIEEEVRRELALPPPDPSPPAPPRRQPCHFRNLDQMVQSLVSHCTCPVQFSMVKVSEGKYRVGDSNTLIFIRILRNHVMVRVGGGWDTLGHYLDKHDPCRCTSLSHKPGSFLKPPAPPVQHEVRVQDGPSQTQPTMTISRSQSPPPPVDWKTYTSSDRRLRPPTPSSPRPRRERGAGTGASREMAPFLRCQERSLIPSWRQPTAGDSPPSPQSSSTQKGRDPQCTSSGKREERYPPELPRGRIPTSWVHEETDSWGTDAGNPTPQRLRAIEATTKGISARGPSPLPRSFGPAECLGLRLPLRDEAKGAFFQFREPESVRSPTPVQGLTKIPIRLPPARPPTPGRSFPGATSGSPRTELGRDPIPLRAVTVDLAGSTHGDCSVEVRQEDQQLDIQVMAEARESWDLGLQEQEGRYTPLPLGGNKEQAIYCSLEEEILGNMKLLEVRSACPQGTRSGVIPRSGVYIPRLAGQWPEPGGPYDKAIQELAQGSPSLLKVDLEAWKAAPTGSPKPAVTPGPGSLKGKLGARQSGPRTKASLSAKGTHMRKVPPQGGQDCSASTVSASPEAPTPSPLDPNSDKAKACLSKGRRTLRKPKRVPSIYKLKLRPRIRPRRDHRPEKQPSRIPRPLAYVFLGPARQPPKDRLLRAVLGSKGGEASRVDGASVGEEEEEGKEEKEPAAPLESSPQPPEGLQPHWLNQAPLPPEEESWV |
| 分子量 | 96.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是模拟生成的3条关于重组人GAS2L2蛋白的参考文献示例(非真实文献，供参考)：
1. **《GAS2L2调控微管稳定性与细胞迁移的功能研究》**
*作者：Zhang Y, et al. (2020)*
摘要：研究揭示了GAS2L2通过其C端GAR结构域与微管相互作用，增强微管稳定性，并影响肿瘤细胞的定向迁移能力。
2. **《重组人GAS2L2蛋白纯化及其在细胞周期阻滞中的作用》**
*作者：Li H, Wang X. (2019)*
摘要：首次报道利用大肠杆菌系统高效表达重组人GAS2L2蛋白，验证其在G2/M期阻滞中的功能，可能与p53信号通路相关。
3. **《GAS2L2与肌动蛋白动态重塑的机制关联》**
*作者：Gupta S, et al. (2021)*
摘要：通过CRISPR敲除实验发现，GAS2L2缺失导致肌动蛋白纤维排列紊乱，提示其在维持细胞极性及胚胎发育中的潜在作用。
注：以上为虚构文献，实际研究中建议通过PubMed或Web of Science以关键词"GAS2L2"或"Growth Arrest-Specific 2 Like 2"检索真实文献。
Growth arrest-specific 2-like 2 (GAS2L2) is a member of the GAS2 protein family, initially identified for their roles in cellular stress responses and cytoskeletal organization. Human GAS2L2. encoded by the GAS2L2 gene, contains a conserved GAS2 domain that enables interaction with microtubules and actin filaments, suggesting its function as a cytoskeletal crosslinker. Studies propose its involvement in regulating cell morphology, mitotic processes, and mechanical stability during division. Unlike other GAS2 family members, GAS2L2 exhibits dynamic localization patterns during the cell cycle, accumulating at the contractile ring during cytokinesis. Dysregulation of GAS2L2 has been tentatively linked to cellular senescence, cancer progression, and developmental defects, though its precise mechanisms remain under investigation. Recombinant human GAS2L2 protein is typically produced using bacterial or mammalian expression systems, enabling in vitro studies of its structure, binding partners, and regulatory pathways. This tool has become essential for exploring its potential as a diagnostic marker or therapeutic target in diseases involving cytoskeletal dysfunction, such as metastatic cancers or fibrotic disorders. Current research also focuses on deciphering its interplay with apoptosis-related pathways and mechanical signaling cascades.
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