关键信息
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基因名
VPS24
- 应用
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别名
VPS24；CGI149；Charged multivesicular body Protein 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y3E7
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表达区间
1-222aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHRKAVSKLYASKAHMNSVLMGMKNQLAVLRV AGSLQKSTEVMKAMQSLVKIPEIQATMRELSKEMMKAGIIEEMLEDTFES MDDQEEMEEEMGLFGKTQEKPPKELVNEWSLKIRKEMRVVDRQIRDIQRE EEKVKRSVKDAAKKGQKDVCIVLAKEMIRSAEMEIDRILFEITAGALGKA PSKVTDALPEPEPPGAMAASEDEEEEEEALEAMQSRLATLRS
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分子量
27 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
VPS24, a key component of the ESCRT-III complex, plays a crucial role in various cellular processes, including the sorting of ubiquitinated proteins, membrane remodeling, and the regulation of cell division. The ESCRT machinery is essential for the budding of viruses and the degradation of damaged organelles, making VPS24 an important protein for maintaining cellular homeostasis. Recent studies have highlighted its involvement in the pathogenesis of several diseases, including cancer and neurodegenerative disorders, where dysregulation of protein sorting and membrane trafficking is often observed. Given its vital functions, understanding the structure and mechanisms of VPS24 can provide insights into potential therapeutic targets. Researchers have focused on characterizing the restructured protein VPS24 to gain a deeper understanding of its interaction with other ESCRT components and its overall role in cellular dynamics. This research not only furthers our understanding of VPS24 itself but also contributes to the broader field of cellular biology, where insights into protein dynamics and interaction networks pave the way for advancements in disease treatment and prevention.
