| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | HNRPAB |
| Uniprot No | Q99729 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-332aa |
| 氨基酸序列 | MSEAGEEQPM ETTGATENGH EAVPEASRGR GWTGAAAGAG GATAAPPSGN QNGAEGDQIN ASKNEEDAGK MFVGGLSWDT SKKDLKDYFT KFGEVVDCTI KMDPNTGRSR GFGFILFKDA ASVEKVLDQK EHRLDGRVID PKKAMAMKKD PVKKIFVGGL NPESPTEEKI REYFGEFGEI EAIELPMDPK LNKRRGFVFI TFKEEEPVKK VLEKKFHTVS GSKCEIKVAQ PKEVYQQQQY GSGGRGNRNR GNRGSGGGGG GGGQSQSWNQ GYGNYWNQGY GYQQGYGPGY GGYDYSPYGY YGYGPGYDYS QGSTNYGKSQ RRGGHQNNYK PY |
| 分子量 | 36.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于重组人HNRPAB(HNRNPAB)蛋白的虚构参考文献示例，包含文献名称、作者及摘要概括：
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1. **文献名称**：*HNRPAB enhances mRNA stability to promote hepatocellular carcinoma metastasis*
**作者**：Liu Y. et al.
**摘要**：研究通过重组人HNRPAB蛋白的体外实验，证实其通过结合靶向mRNA的3'UTR区域提高其稳定性，从而促进肝癌细胞的侵袭和转移。
2. **文献名称**：*Structural analysis of recombinant HNRNPAB reveals RNA-binding domain specificity*
**作者**：Zhang R. et al.
**摘要**：利用重组HNRNPAB蛋白进行晶体结构解析，明确了其RRM结构域与单链RNA结合的特异性机制，为开发靶向RNA-蛋白相互作用的药物提供依据。
3. **文献名称**：*HNRNPAB regulates embryonic stem cell differentiation via alternative splicing*
**作者**：Kim J. et al.
**摘要**：通过重组蛋白功能回补实验，发现HNRNPAB调控胚胎干细胞多能性相关基因的选择性剪接，影响其向中胚层分化的过程。
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注：以上内容为示例，实际文献需根据具体研究通过学术数据库(如PubMed、Web of Science)检索确认。
Heterogeneous nuclear ribonucleoprotein AB (hnRNPAB), also known as ABCF1 or HTRPAB, is a member of the hnRNP family involved in RNA metabolism. Encoded by the HNRNPAB gene in humans (chromosome 5q35.3), this protein contains RNA recognition motifs (RRMs) that enable binding to RNA and single-stranded DNA. It regulates mRNA processing, stability, transport, and translation, playing critical roles in cell cycle progression, stress responses, and maintenance of genomic integrity. Studies link hnRNPAB to cancer progression, where its overexpression promotes metastasis and chemoresistance, and neurodegenerative disorders like amyotrophic lateral sclerosis (ALS).
Recombinant human hnRNPAB protein is produced via expression systems (e.g., *E. coli* or mammalian cells), often fused with tags (e.g., His-tag) for purification. Its recombinant form retains RNA/DNA-binding activity and is used to study RNA-protein interactions, post-transcriptional regulation, and molecular mechanisms in disease models. It also serves as an antigen for antibody generation. Research applications include elucidating hnRNPAB's roles in DNA repair, telomere maintenance, and alternative splicing. Dysregulation of hnRNPAB is associated with poor prognosis in cancers, making its recombinant form a tool for drug screening or biomarker studies. Optimized recombinant variants may mimic phosphorylation states or mutations observed in pathological conditions.
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