关键信息
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基因名
PKD1L2
- 应用
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别名
PKD1L2; KIAA1879; PC1L2; Polycystic kidney disease protein 1-like 2; PC1-like 2 protein; Polycystin-1L2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7Z442
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表达区间
1-306 aa
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氨基酸序列
MGEDSPVAMFSWYLDNTPTEQAEPLPDACRLRGFWPRSLTLLQSNTSTLLLNSSFLQSRGEVIRIRATALTRHAYGEDTYVISTVPPREVPACTIAPEEGTVLTSFAIFCNASTALGPLEFCFCLESGSCLHCGPEPALPSVYLPLGEENNDFVLTVVISATNRAGDTQQTQAMAKVALGDTCVEDVAFQAAVSEKIPTALQGEGGPEQLLQLAKAVSSMLNQEHESQGSGQSLSIDVRQKVREHVLGSLSAVTTGLEDVQRVQELAEVLREVTCRSKELTPSAQGSCMGDSWEGAPPAAHVSHAR
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分子量
59.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
PKD1L2, or Polycystic Kidney Disease 1-Like 2, is a gene that encodes a protein closely associated with the polycystic kidney disease (PKD) phenotype. This disease is characterized by the formation of fluid-filled cysts in the kidneys, leading to renal dysfunction. Research into PKD1L2 has gained momentum due to its potential role in kidney development and function, as well as its involvement in ciliopathies—a group of disorders linked to dysfunctional cilia. The protein is believed to play a critical role in cellular signaling pathways related to kidney epithelial cells, influencing their proliferation and differentiation. Understanding the structure and function of PKD1L2 is vital for unraveling the molecular mechanisms that contribute to PKD and may open avenues for novel therapeutic strategies. Furthermore, studying the recombinant PKD1L2 protein allows researchers to examine its biological activity and interactions with other cellular components more closely. As a result, the investigation of PKD1L2 not only enhances our comprehension of renal pathophysiology but also holds promise for the development of targeted treatments for PKD and related disorders. This research ultimately aims to improve diagnostics and therapeutic interventions, benefiting those affected by this genetic condition.
