关键信息
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基因名
BIRC4BP
- 应用
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别名
BIRC 4 binding Protein; BIRC4 binding Protein; BIRC4-binding Protein; BIRC4BP; HSXIAPAF 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6GPH4
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表达区间
1-301aa
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氨基酸序列
MEGDFSVCRN CKRHVVSANF TLHEAYCLRF LVLCPECEEP VPKETMEEHC KLEHQQVGCT MCQQSMQKSS LEFHKANECQ ERPVECKFCK LDMQLSKLEL HESYCGSRTE LCQGCGQFIM HRMLAQHRDV CRSEQAQLGK GERISAPERE IYCHYCNQMI PENKYFHHMG KCCPDSEFKK HFPVGNPEIL PSSLPSQAAE NQTSTMEKDV RPKTRSINRF PLHSESSSKK APRSKNKTLD PLLMSEPKPR TSSPRGDKAA YDILRRCSQC GILLPLPILN QHQEKCRWLA SSKGKQVRNF S
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分子量
34.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
BIRC4BP, also known as Baculoviral IAP Repeat Containing 4 Binding Protein, is an important regulator of cell survival and apoptosis. It has gained significant attention in recent years due to its role in various cellular processes, including cancer progression, immune response, and neurotransmission. This protein functions by interacting with inhibitors of apoptosis proteins (IAPs), modulating their activity, and influencing signaling pathways involved in cell death. Research has shown that BIRC4BP can have oncogenic properties, promoting tumor cell proliferation and survival under stress conditions, making it a potential target for therapeutic intervention in cancer. Additionally, BIRC4BP's involvement in immune responses highlights its potential role in autoimmune diseases and infectious diseases. The production of recombinant BIRC4BP proteins allows for detailed studies of its structure and function, aiding in the development of small molecule inhibitors or monoclonal antibodies that could disrupt its interactions with IAPs. Such advancements could lead to novel treatments that enhance apoptosis in cancer cells or modulate immune responses. Overall, the study of BIRC4BP is pivotal for understanding complex biological processes and developing targeted therapies in oncology and immunology.
