关键信息
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基因名
COL18A1
- 应用
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别名
COL18A1；Collagen alpha-1(XVIII) chain
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P39060
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表达区间
1578-1754aa
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氨基酸序列
QPVLHLVALNSPLSGGMRGIRGADFQCFQQARAVGLAGTFRAFLSSRLQD LYSIVRRADRAAVPIVNLKDELLFPSWEALFSGSEGPLKPGARIFSFDGK DVLRHPTWPQKSVWHGSDPNGRRLTESYCETWRTEAPSATGQASSLLGGR LLGQSAASCHHAYIVLCIENSFMTASK
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分子量
21 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
COL18A1, a member of the collagen family, encodes a protein that is crucial for the structural integrity of the extracellular matrix (ECM). It plays a significant role in various biological processes, including tissue repair, angiogenesis, and tumorigenesis. Abnormal expression or mutations in COL18A1 have been linked to several pathological conditions, particularly in the context of cancer, where it can influence tumor growth and metastasis by modulating ECM dynamics and cellular interactions. The protein contains specific domains that facilitate its interaction with other ECM components and growth factors, making it a potential therapeutic target. Recent studies have explored the use of recombinant COL18A1 protein to investigate its functions in vitro and in vivo, providing insights into its role in cancer biology and tissue engineering applications. By understanding the mechanisms underlying COL18A1's activity, researchers aim to develop novel strategies for cancer diagnosis and treatment, as well as to harness its properties in regenerative medicine. Thus, ongoing research into COL18A1 recombinant protein is crucial for elucidating its functions and therapeutic potential in both oncological and developmental contexts.
