关键信息
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基因名
Tnc
- 应用
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别名
Tnc；CAGL79；KIAA1856；Trinucleotide repeat-containing gene 18 Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P24821
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表达区间
1888-2201aa
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氨基酸序列
DSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA
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分子量
39.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Tnc, or Tenascin-C, is an extracellular matrix protein that plays a critical role in various biological processes, including tissue development, repair, and immune responses. Its expression is highly regulated during embryogenesis and is typically downregulated in healthy adult tissues, reappearing in pathological conditions such as cancer and inflammation. Research has indicated that Tnc interacts with a variety of cell types and affects signaling pathways that govern cell adhesion, migration, and proliferation. Notably, its overexpression in tumors is associated with increased metastasis and poor prognosis, making Tnc a potential biomarker for cancer progression. Additionally, Tnc has been implicated in various diseases beyond cancer, such as cardiovascular disorders, autoimmune diseases, and wound healing. Studies on Tnc have involved the exploration of its structural properties, molecular interactions, and potential as a therapeutic target. The recombinant production of Tnc proteins has enabled researchers to investigate its functional roles in vitro and in vivo more effectively, paving the way for novel therapeutic strategies that could manipulate Tnc's activities. This growing body of research aims to elucidate the complex roles of Tnc in health and disease, ultimately contributing to the development of targeted interventions that leverage its unique properties.
