Recombinant Human LOC387907 Protein

Recombinant human LOC387907 protein, also recognized as RGR (Retinal G protein-coupled receptor), is a membrane-associated protein predominantly expressed in the retinal pigment epithelium (RPE) and Müller cells of the retina. It belongs to the rhodopsin-like G protein-coupled receptor (GPCR) family and plays a critical role in visual cycle regulation, particularly in retinoid metabolism. LOC387907 is implicated in the isomerization of all-trans-retinal to 11-cis-retinal, a vital process for photoreceptor regeneration. Genetic studies link mutations in the LOC387907 gene to age-related macular degeneration (AMD), notably through the high-risk haplotype involving the adjacent HTRA1 and ARMS2 genes. Its association with oxidative stress responses and drusen formation underscores its potential role in AMD pathogenesis. Recombinant LOC387907 protein is typically produced via heterologous expression systems (e.g., E. coli, mammalian cells) for functional studies, enabling structural characterization, ligand-binding assays, and mechanistic exploration of AMD-related pathways. Current research focuses on elucidating its precise biochemical function, interaction with retinal proteins, and therapeutic targeting to mitigate degenerative retinal disorders. The recombinant form serves as a key tool in modeling disease mechanisms and screening potential drug candidates.