Recombinant Human LOC91149 Protein

Recombinant human LOC91149 protein, encoded by the LOC91149 gene (currently annotated as a putative open reading frame in genomic databases), represents a less-studied biomolecule with emerging research interest. While its exact physiological role remains unclear, bioinformatic analyses suggest it may belong to the ribosomal protein family, potentially involved in translation regulation or ribosome biogenesis. The protein is predicted to contain conserved structural motifs shared with known ribosomal components, including alpha-helical domains and basic residue clusters characteristic of RNA-binding proteins. Recombinant production of LOC91149 typically employs Escherichia coli or mammalian expression systems with affinity tags (e.g., His-tag) for purification. This engineered protein enables functional studies to elucidate its interactions with ribosomal subunits, nucleic acids, or potential partners in cellular stress responses. Preliminary evidence links LOC91149 expression variations to certain cancers and neurodegenerative conditions, though mechanistic insights remain speculative. Its recombinant form serves as critical material for antibody development, crystallography attempts, and pathway analysis in disease models. Current research focuses on validating its subcellular localization (predominantly nucleolar), post-translational modifications, and possible moonlighting functions beyond ribosomal contexts. Limited literature emphasizes the need for standardized nomenclature, as some studies reference this protein under legacy identifiers or species-specific homologs.