关键信息
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基因名
PRKD2
- 应用
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别名
DKFZp586E0820; HSPC187; KPCD2_HUMAN; nPKC D2; nPKC-D2; PKD2; PRKD 2; Prkd2; Protein kinase D2; Serine/threonine protein kinase D2; Serine/threonine-protein kinase D2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BZL6
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表达区间
1-878 aa
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氨基酸序列
MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL
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分子量
123.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
PRKD2, or Protein Kinase D2, is a serine/threonine kinase that plays a critical role in various cellular processes, including cell proliferation, differentiation, and survival. It is part of the protein kinase D family, which is known to be involved in cellular signaling pathways linked to cancer, inflammation, and cardiovascular diseases. The study of PRKD2 has become increasingly important due to its potential as a therapeutic target in these conditions. Previous research has shown that PRKD2 can influence the behavior of cancer cells by regulating key pathways such as the NF-κB and β-catenin signaling cascades. Furthermore, aberrant expression or activity of PRKD2 is associated with various malignancies, making it a candidate for biomarker development and targeted therapies. Understanding the structure and functional mechanisms of recombinant PRKD2 protein provides vital insights into its roles in pathological processes. This knowledge facilitates the design of specific inhibitors to modulate its activity, offering a promising avenue for novel treatment strategies in diseases influenced by PRKD2 dysregulation. Given its multifaceted roles in signaling, ongoing investigations into PRKD2 may uncover new roles in cellular homeostasis and disease progression, thereby enhancing our understanding of its biological significance and therapeutic potential.
