Cat: PA2000-2018

Recombinant Human hamp Protein,His

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关键信息

  • 基因名

    hamp

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    hamp;FPN;FPN1;IREG1;Solute carrier family 40 member 1

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P81172

  • 表达区间

    60-84aa

  • 氨基酸序列

    DTHFPICIFCCGCCHRSKCGMCCKT

  • 分子量

    29.5 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

HAMP (hepcidin antimicrobial peptide) is a crucial protein involved in iron homeostasis and the innate immune response, primarily produced by the liver in response to various stimuli, including inflammation and iron levels. Research into HAMP has gained significance due to its role in regulating iron metabolism, which is vital for various physiological functions, including oxygen transport and cellular respiration. Dysregulation of HAMP can lead to iron overload disorders, such as hereditary hemochromatosis, or anemia of chronic disease, highlighting its importance in both health and disease. Additionally, HAMP's antimicrobial properties suggest its potential in combating infections. As a peptide that influences ferroportin, the only known iron exporter, understanding HAMP’s structure and function can unlock new avenues for therapeutic interventions in iron-related diseases. Recent advancements in recombinant protein technology have facilitated the production of HAMP, enabling researchers to explore its functions and mechanisms more intricately. Investigations into HAMP's interactions with other proteins and its impact on cellular iron regulation are ongoing, providing insights into the complex network of iron metabolism and its implications in human health.

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