| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PAQR4 |
| Uniprot No | Q8N4S7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-273 aa |
| 活性数据 | MAFLAGPRLLDWASSPPHLQFNKFVLTGYRPASSGSGCLRSLFYLHNELGNIYTHGLALL GFLVLVPMTMPWGQLGKDGWLGGTHCVACLAPPAGSVLYHLFMCHQGGSAVYARLLALDM CGVCLVNTLGALPIIHCTLACRPWLRPAALVGYTVLSGVAGWRALTAPSTSARLRAFGWQ AAARLLVFGARGVGLGSGAPGSLPCYLRMDALALLGGLVNVARLPERWGPGRFDYWGNSH QIMHLLSVGSILQLHAGVVPDLLWAAHHACPRD |
| 分子量 | 29.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于PAQR4蛋白的参考文献示例(部分为虚构，仅作格式参考)：
1. **"Structural characterization of PAQR4 reveals its role in adiponectin signaling"**
*作者：Li X et al. (2020)*
**摘要**：本研究解析了PAQR4蛋白的晶体结构，发现其通过与脂联素结合激活下游AMPK通路，调控肝脏糖脂代谢平衡，提示其在代谢综合征中的潜在作用。
2. **"PAQR4 promotes lung cancer progression via mTORC1 activation"**
*作者：Wang Y et al. (2019)*
**摘要**：通过细胞和动物模型证实PAQR4在非小细胞肺癌中高表达，通过激活mTORC1信号通路促进肿瘤细胞增殖和转移，其表达水平与患者预后不良相关。
3. **"PAQR4 interacts with RACK1 to regulate autophagy under metabolic stress"**
*作者：Zhang R et al. (2021)*
**摘要**：发现PAQR4与支架蛋白RACK1相互作用，在营养匮乏条件下抑制自噬，维持癌细胞存活，为靶向癌症代谢疗法提供新思路。
4. **"PAQR4 deficiency ameliorates insulin resistance in obese mice"**
*作者：Kim S et al. (2018)*
**摘要**：构建PAQR4基因敲除小鼠模型，发现其在高脂饮食下表现出胰岛素敏感性提高和脂肪炎症减轻，提示抑制PAQR4可能改善肥胖相关代谢紊乱。
注：以上为示例性内容，实际文献需通过PubMed或Google Scholar检索确认。
PAQR4 (Progestin and AdipoQ Receptor 4), a member of the PAQR protein family, is a membrane-associated receptor implicated in regulating cellular signaling and metabolic processes. Structurally, PAQR4 belongs to the seven-transmembrane receptor class, sharing homology with adiponectin receptors (AdipoRs) and progesterone membrane receptors. While its precise physiological ligands remain under investigation, PAQR4 is hypothesized to interact with lipid-derived molecules or hormones to modulate downstream pathways. Research suggests its involvement in cancer progression, particularly through interactions with oncogenic signaling cascades such as PI3K/AKT and Wnt/β-catenin, which drive cell proliferation, survival, and metastasis. Overexpression of PAQR4 has been observed in multiple cancers, including breast, lung, and colorectal tumors, correlating with poor prognosis and therapy resistance. Additionally, PAQR4 may influence metabolic homeostasis, potentially linking it to obesity-related disorders. Its dual role in metabolism and oncogenesis highlights its potential as a therapeutic target. However, the molecular mechanisms underlying PAQR4's functions—including ligand specificity, receptor activation, and crosstalk with other signaling networks—are not fully elucidated. Current studies focus on unraveling its structure-function relationships and validating its utility in diagnostics or targeted therapies. As an emerging player in cellular signaling, PAQR4 represents a promising yet underexplored node bridging metabolic regulation and disease pathology.
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