| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PCDH8 |
| Uniprot No | O95206 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-1070 aa |
| 活性数据 | MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGCPAADAPPPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV |
| 分子量 | 139.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于人原钙粘蛋白8(PCDH8)的示例参考文献，内容基于已有研究领域概括(具体信息需通过学术数据库验证)：
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1. **文献名称**：*Protocadherin-8 regulates synaptic function through interactions with postsynaptic density proteins*
**作者**：Smith A et al. (2021)
**摘要**：该研究阐明了PCDH8通过与PSD-95等突触后蛋白相互作用调控突触可塑性的机制，发现其在神经元网络形成中的关键作用。
2. **文献名称**：*PCDH8 methylation as a potential biomarker in glioblastoma progression*
**作者**：Zhang L et al. (2019)
**摘要**：揭示了PCDH8基因启动子区域的甲基化异常与胶质母细胞瘤恶性程度的相关性，表明其可能作为肿瘤预后标志物。
3. **文献名称**：*Structural basis of PCDH8 homophilic adhesion in neural development*
**作者**：Yamamoto K et al. (2018)
**摘要**：通过晶体结构解析，证明PCDH8的同源二聚化特性对其在轴突导向和神经回路建立中的功能至关重要。
4. **文献名称**：*Protocadherin-8 deficiency leads to autistic-like behaviors in mice*
**作者**：Chen R et al. (2016)
**摘要**：构建PCDH8基因敲除小鼠模型，发现其社会交互和重复行为异常，提示PCDH8与自闭症谱系障碍的潜在关联。
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**说明**：以上文献信息为示例，实际引用时请通过PubMed或Google Scholar核实准确标题、作者及摘要内容。研究领域主要集中在神经发育、癌症和结构生物学方向，需根据研究主题筛选。
Protocadherin-8 (PCDH8), a member of the protocadherin family within the cadherin superfamily, is a calcium-dependent cell adhesion protein predominantly expressed in the central nervous system. It plays critical roles in neural circuit formation, synaptic plasticity, and brain development by mediating homophilic interactions between neurons. Structurally, PCDH8 contains six extracellular cadherin repeats, a transmembrane domain, and a cytoplasmic tail with conserved motifs for intracellular signaling. Its expression is tightly regulated during embryogenesis and in adult tissues, with high abundance in regions like the hippocampus and cerebral cortex.
As a "clustered" protocadherin, PCDH8 contributes to neuronal diversity and connectivity through stochastic gene-promoter interactions, ensuring precise synaptic specificity. Dysregulation of PCDH8 has been linked to neurodevelopmental disorders, including autism spectrum disorders and schizophrenia, as well as cancer progression via aberrant cell adhesion and signaling pathways. Recombinant human PCDH8 protein, typically produced in mammalian expression systems, retains native folding and functionality, enabling in vitro studies on cell-cell interactions, axonal guidance, and disease mechanisms. It serves as a vital tool for structural analyses, antibody development, and therapeutic target validation, bridging molecular insights with potential clinical applications in neuroscience and oncology.
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