| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PDZD4 |
| Uniprot No | Q76G19 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-769 aa |
| 活性数据 | MGCNMCVVQK PEEQYKVMLQ VNGKELSKLS QEQTLQALRS SKEPLVIQVL RRSPRLRGDS SCHDLQLVDS GTQTDITFEH IMALGKLRPP TPPMVILEPP PISHEYYDPA EFMEGGPQEA DRLDELEYEE VELYKSSHRD KLGLMVCYRT DDEEDLGIYV GEVNPNSIAA KDGRIREGDR IIQINGVDVQ NREEAVAILS QEENTNISLL VARPESQLAK RWKDSDRDDF LDDFGSENEG ELRARKLKSP PAQQPGNEEE KGAPDAGPGL SNSQELDSGV GRTDESTRNE ESSEHDLLGD EPPSSTNTPG SLRKFGLQGD ALQSRDFHFS MDSLLAEGAG LGGGDVPGLT DEEYERYREL LEIKCHLENG NQLGLLFPRA SGGNSALDVN RNESLGHEMA MLEEELRHLE FKCRNILRAQ KMQQLRERCM KAWLLEEESL YDLAASEPKK HELSDISELP EKSDKDSTSA YNTGESCRST PLLVEPLPES PLRRAMAGNS NLNRTPPGPA VATPAKAAPP PGSPAKFRSL SRDPEAGRRQ HAEERGRRNP KTGLTLERVG PESSPYLSRR HRGQGQEGEH YHSCVQLAPT RGLEELGHGP LSLAGGPRVG GVAAAATEAP RMEWKVKVRS DGTRYVAKRP VRDRLLKARA LKIREERSGM TTDDDAVSEM KMGRYWSKEE RKQHLIRARE QRKRREFMMQ SRLECLREQQ NGDSKPELNI IALSHRKTMK KRNKKILDNW ITIQEMLAHG ARSADGKRVY NPLLSVTTV |
| 分子量 | 86.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人PDZD4蛋白的3篇参考文献的简要总结(基于公开研究资料及类似领域文献的模拟示例)：
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1. **文献名称**：*PDZD4 interacts with Cdc42 and regulates cancer cell migration and invasion*
**作者**：Li, X., Zhang, Y., & Wang, H.
**摘要**：研究揭示了PDZD4通过其PDZ结构域与细胞极性调控因子Cdc42结合，影响肿瘤细胞迁移和侵袭。重组PDZD4蛋白在实验中证实可调控Rho GTPase信号通路，为癌症转移机制提供了新见解。
2. **文献名称**：*Structural and functional characterization of the PDZD4 protein in neuronal synapses*
**作者**：Sato, T., et al.
**摘要**：通过体外重组表达PDZD4.分析了其PDZ结构域的晶体结构及与突触后蛋白PSD-95的相互作用，表明PDZD4可能参与突触可塑性和神经发育相关调控。
3. **文献名称**：*PDZD4 as a potential biomarker in colorectal cancer: Expression and clinical significance*
**作者**：Chen, L., et al.
**摘要**：研究利用重组PDZD4蛋白制备抗体，发现PDZD4在结直肠癌组织中高表达，且其表达水平与患者预后不良相关，提示其作为治疗靶点的潜力。
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**注意**：以上文献为示例性概括，实际研究可能需通过数据库(如PubMed、Web of Science)以“PDZD4”或“recombinant PDZD4”为关键词检索最新成果。若需具体文献，建议提供更详细的研究背景或访问学术数据库获取。
Recombinant human PDZD4 protein is a biologically engineered form of the PDZ domain-containing protein 4. a member of the PDZ protein family characterized by the presence of PDZ domains—structural motifs that mediate protein-protein interactions. These domains typically facilitate the assembly of multi-protein complexes, playing roles in signaling pathways, cellular polarity, and membrane trafficking. PDZD4 contains multiple PDZ domains alongside additional regions, such as a conserved N-terminal L27 domain, which may coordinate its interactions within larger protein networks. The recombinant version is commonly produced using heterologous expression systems (e.g., Escherichia coli or mammalian cell lines) followed by purification techniques like affinity chromatography, ensuring high purity and activity for research applications.
Functionally, PDZD4 is implicated in regulating cellular processes like vesicle transport, receptor localization, and signal transduction. Studies suggest its involvement in neuronal development and cancer progression, where dysregulation of PDZ domain proteins often correlates with disease mechanisms. For instance, PDZD4 may interact with transmembrane receptors or cytoskeletal components, acting as a scaffold to modulate downstream pathways. While its precise physiological roles remain under investigation, recombinant PDZD4 serves as a critical tool for dissecting its molecular interactions and structural properties. Current research focuses on mapping its binding partners, understanding its contribution to cellular homeostasis, and exploring its potential as a therapeutic target or diagnostic marker in pathologies linked to disrupted protein trafficking or signaling.
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