关键信息
-
基因名
RFX2
- 应用
-
别名
DNA-binding protein RFX2; HLA class II regulatory factor RFX2; regulatory factor X 2 (influences HLA class II expression); Regulatory factor X 2; regulatory factor X2; RFX2; RFX2_HUMAN; trans acting regulatory factor 2
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P48378
-
表达区间
1-723 aa
-
氨基酸序列
MQNSEGGADS PASVALRPSA AAPPVPASPQ RVLVQAASSN PKGAQMQPIS LPRVQQVPQQ VQPVQHVYPA QVQYVEGGDA VYTNGAIRTA YTYNPEPQMY APSSTASYFE APGGAQVTVA ASSPPAVPSH SMVGITMDVG GSPIVSSAGA YLIHGGMDST RHSLAHTSRS SPATLEMAIE NLQKSEGITS HKSGLLNSHL QWLLDNYETA EGVSLPRSSL YNHYLRHCQE HKLDPVNAAS FGKLIRSVFM GLRTRRLGTR GNSKYHYYGI RLKPDSPLNR LQEDTQYMAM RQQPMHQKPR YRPAQKTDSL GDSGSHSGLH STPEQTMAVQ SQHHQQYIDV SHVFPEFPAP DLGSFLLQDG VTLHDVKALQ LVYRRHCEAT VDVVMNLQFH YIEKLWLSFW NSKASSSDGP TSLPASDEDP EGAVLPKDKL ISLCQCDPIL RWMRSCDHIL YQALVEILIP DVLRPVPSTL TQAIRNFAKS LEGWLTNAMS DFPQQVIQTK VGVVSAFAQT LRRYTSLNHL AQAARAVLQN TSQINQMLSD LNRVDFANVQ EQASWVCQCE ESVVQRLEQD FKLTLQQQSS LDQWASWLDS VVTQVLKQHA GSPSFPKAAR QFLLKWSFYS SMVIRDLTLR SAASFGSFHL IRLLYDEYMF YLVEHRVAEA TGETPIAVMG EFNDLASLSL TLLDKDDMGD EQRGSEAGPD ARSLGEPLVK RERSDPNHSL QGI
-
分子量
79.9 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
RFX2 (Regulatory Factor X 2) is a critical transcription factor that plays a pivotal role in the regulation of immune responses and the development of specific tissues. Its involvement in the expression of MHC class II genes is particularly noteworthy, as this process is essential for the presentation of antigens to T cells, thereby initiating adaptive immune responses. Given the significance of MHC class II in immune regulation, dysregulation or mutations in RFX2 can lead to immunological disorders, including autoimmune diseases and impaired immune responses. Recent studies have shown that RFX2 is not only crucial for immune system function but also for various cellular processes, including cell differentiation and development. The production of recombinant RFX2 protein has become a focus of research, facilitating investigations into its biochemical properties and functions. Understanding RFX2's mechanisms of action supports the development of potential therapeutic strategies targeting immune-related diseases. Moreover, recombinant RFX2 protein serves as a valuable tool for studying its interactions with other proteins and elucidating its role in transcriptional regulation. As research progresses, insights gained from RFX2 studies may contribute to innovative treatments for conditions associated with immune dysfunction, highlighting the importance of this protein in both fundamental biology and clinical applications.
